What factors are predictive of surgical resection and survival from localised nonsmall cell lung cancer?

David C. Currow, Hui You, Sanchia Aranda, Brian C. McCaughan, Stephen Morrell, Deborah F. Baker, Richard Walton, David M. Roder

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To investigate opportunities to reduce lung cancer mortality after diagnosis of localised non-small cell lung cancer (NSCLC) in New South Wales through surgical resection.

Main outcome measures: Resection rates and lung cancer mortality.

Design, patients and setting: In this cohort study, resection rates and lung cancer mortality risk were explored using multivariate logistic regression and competing risk regression, respectively. Data for 3040 patients were extracted from the NSW Central Cancer Registry for the diagnostic period 1 January 2003 to 31 December 2007. Subset analyses for patients at low surgical risk indicated resection rates and outcomes under ideal circumstances.

Results: The resection rate in NSW was estimated to be between 38% and 43%, peaking at 59% by local health district (LHD) of residence. Not having a resection was associated with older age, lower socioeconomic status, lack of private health insurance, and residence by LHD. Adjusted 5-year cumulated probabilities of death were 76% in absence of resection, 30% for wedge resection, 18% for segmental resection, 22% for lobectomy and 45% for pneumonectomy. Of 255 “low surgical risk” patients, 71% had a resection. Those not receiving a resection had a higher probability of death (adjusted subhazard ratio, 14.1; 95% CI, 7.2–27.5). If the low overall resection rate of 38%–43% in NSW were increased to 59% (the highest LHD resection rate), the proportion of all patients with localised NSCLC dying of NSCLC in the 5 years from diagnosis would decrease by about 10%, based on differences in probabilities of death by resection estimated in this study.

Conclusions: Potential exists to reduce deaths from NSCLC in NSW through increased resection.

LanguageEnglish
Pages475-480
Number of pages6
JournalMedical Journal of Australia
Volume201
Issue number8
DOIs
Publication statusPublished - 1 Jan 2014

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Currow, David C. ; You, Hui ; Aranda, Sanchia ; McCaughan, Brian C. ; Morrell, Stephen ; Baker, Deborah F. ; Walton, Richard ; Roder, David M. / What factors are predictive of surgical resection and survival from localised nonsmall cell lung cancer?. In: Medical Journal of Australia. 2014 ; Vol. 201, No. 8. pp. 475-480.
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title = "What factors are predictive of surgical resection and survival from localised nonsmall cell lung cancer?",
abstract = "Objective: To investigate opportunities to reduce lung cancer mortality after diagnosis of localised non-small cell lung cancer (NSCLC) in New South Wales through surgical resection.Main outcome measures: Resection rates and lung cancer mortality.Design, patients and setting: In this cohort study, resection rates and lung cancer mortality risk were explored using multivariate logistic regression and competing risk regression, respectively. Data for 3040 patients were extracted from the NSW Central Cancer Registry for the diagnostic period 1 January 2003 to 31 December 2007. Subset analyses for patients at low surgical risk indicated resection rates and outcomes under ideal circumstances.Results: The resection rate in NSW was estimated to be between 38{\%} and 43{\%}, peaking at 59{\%} by local health district (LHD) of residence. Not having a resection was associated with older age, lower socioeconomic status, lack of private health insurance, and residence by LHD. Adjusted 5-year cumulated probabilities of death were 76{\%} in absence of resection, 30{\%} for wedge resection, 18{\%} for segmental resection, 22{\%} for lobectomy and 45{\%} for pneumonectomy. Of 255 “low surgical risk” patients, 71{\%} had a resection. Those not receiving a resection had a higher probability of death (adjusted subhazard ratio, 14.1; 95{\%} CI, 7.2–27.5). If the low overall resection rate of 38{\%}–43{\%} in NSW were increased to 59{\%} (the highest LHD resection rate), the proportion of all patients with localised NSCLC dying of NSCLC in the 5 years from diagnosis would decrease by about 10{\%}, based on differences in probabilities of death by resection estimated in this study.Conclusions: Potential exists to reduce deaths from NSCLC in NSW through increased resection.",
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Currow, DC, You, H, Aranda, S, McCaughan, BC, Morrell, S, Baker, DF, Walton, R & Roder, DM 2014, 'What factors are predictive of surgical resection and survival from localised nonsmall cell lung cancer?', Medical Journal of Australia, vol. 201, no. 8, pp. 475-480. https://doi.org/10.5694/mja14.00365

What factors are predictive of surgical resection and survival from localised nonsmall cell lung cancer? / Currow, David C.; You, Hui; Aranda, Sanchia; McCaughan, Brian C.; Morrell, Stephen; Baker, Deborah F.; Walton, Richard; Roder, David M.

In: Medical Journal of Australia, Vol. 201, No. 8, 01.01.2014, p. 475-480.

Research output: Contribution to journalArticle

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AU - You, Hui

AU - Aranda, Sanchia

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AU - Baker, Deborah F.

AU - Walton, Richard

AU - Roder, David M.

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N2 - Objective: To investigate opportunities to reduce lung cancer mortality after diagnosis of localised non-small cell lung cancer (NSCLC) in New South Wales through surgical resection.Main outcome measures: Resection rates and lung cancer mortality.Design, patients and setting: In this cohort study, resection rates and lung cancer mortality risk were explored using multivariate logistic regression and competing risk regression, respectively. Data for 3040 patients were extracted from the NSW Central Cancer Registry for the diagnostic period 1 January 2003 to 31 December 2007. Subset analyses for patients at low surgical risk indicated resection rates and outcomes under ideal circumstances.Results: The resection rate in NSW was estimated to be between 38% and 43%, peaking at 59% by local health district (LHD) of residence. Not having a resection was associated with older age, lower socioeconomic status, lack of private health insurance, and residence by LHD. Adjusted 5-year cumulated probabilities of death were 76% in absence of resection, 30% for wedge resection, 18% for segmental resection, 22% for lobectomy and 45% for pneumonectomy. Of 255 “low surgical risk” patients, 71% had a resection. Those not receiving a resection had a higher probability of death (adjusted subhazard ratio, 14.1; 95% CI, 7.2–27.5). If the low overall resection rate of 38%–43% in NSW were increased to 59% (the highest LHD resection rate), the proportion of all patients with localised NSCLC dying of NSCLC in the 5 years from diagnosis would decrease by about 10%, based on differences in probabilities of death by resection estimated in this study.Conclusions: Potential exists to reduce deaths from NSCLC in NSW through increased resection.

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