Abstract
Preeclampsia has been suggested to result from a partial breakdown of tolerance to the developing fetus after maternal immune maladaptation. Several of the proposed immunomodulatory properties of the hormonal vitamin D system could potentially have beneficial effects for successful maintenance of pregnancy. Preeclampsia is characterized by marked changes in vitamin D metabolism. This paper reviews the evidence suggesting that the immunomodulatory properties of 1,25(OH)2D may play a key role in maintaining immunological tolerance in pregnancy, and proposes that ensuring adequate vitamin D status/intake may help in the prevention and management of preeclampsia.
Original language | English |
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Pages (from-to) | 225-232 |
Number of pages | 8 |
Journal | Nutrition Reviews |
Volume | 63 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Jul 2005 |
Keywords
- Preeclampsia
- Pregnancy
- Prevention
- Vitamin D
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics