Vitamin D for the prevention of preeclampsia? A hypothesis

Elina Hyppönen

doi:10.1301/nr.2005.jul.225-232

Vitamin D for the prevention of preeclampsia? A hypothesis

Elina Hyppönen

Research output: Contribution to journal › Review article

67 Citations (Scopus)

Abstract

Preeclampsia has been suggested to result from a partial breakdown of tolerance to the developing fetus after maternal immune maladaptation. Several of the proposed immunomodulatory properties of the hormonal vitamin D system could potentially have beneficial effects for successful maintenance of pregnancy. Preeclampsia is characterized by marked changes in vitamin D metabolism. This paper reviews the evidence suggesting that the immunomodulatory properties of 1,25(OH)₂D may play a key role in maintaining immunological tolerance in pregnancy, and proposes that ensuring adequate vitamin D status/intake may help in the prevention and management of preeclampsia.

Original language	English
Pages (from-to)	225-232
Number of pages	8
Journal	Nutrition Reviews
Volume	63
Issue number	7
DOIs	https://doi.org/10.1301/nr.2005.jul.225-232
Publication status	Published - 1 Jul 2005

Keywords

Preeclampsia
Pregnancy
Prevention
Vitamin D

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

Access to Document

10.1301/nr.2005.jul.225-232

Link to publication in Scopus

Cite this

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