Vitamin D for the prevention of preeclampsia? A hypothesis

    Research output: Contribution to journalReview articlepeer-review

    67 Citations (Scopus)


    Preeclampsia has been suggested to result from a partial breakdown of tolerance to the developing fetus after maternal immune maladaptation. Several of the proposed immunomodulatory properties of the hormonal vitamin D system could potentially have beneficial effects for successful maintenance of pregnancy. Preeclampsia is characterized by marked changes in vitamin D metabolism. This paper reviews the evidence suggesting that the immunomodulatory properties of 1,25(OH)2D may play a key role in maintaining immunological tolerance in pregnancy, and proposes that ensuring adequate vitamin D status/intake may help in the prevention and management of preeclampsia.

    Original languageEnglish
    Pages (from-to)225-232
    Number of pages8
    JournalNutrition Reviews
    Issue number7
    Publication statusPublished or Issued - 1 Jul 2005


    • Preeclampsia
    • Pregnancy
    • Prevention
    • Vitamin D

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics

    Cite this