Vitamin D and common mental disorders in mid-life: Cross-sectional and prospective findings

Jane Maddock, Diane J. Berry, Marie Claude Geoffroy, Chris Power, Elina Hyppönen

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    38 Citations (Scopus)


    Background & aims: The relationship between vitamin D and common mental disorders (CMDs) remains unclear. We aimed to determine if behaviours affecting vitamin D concentrations differ between individuals with or without CMDs and evaluate, cross-sectionally and prospectively, the extent to which the association between 25(OH)D and CMDs are explained by these behaviours. Methods: Data are from the 1958 British birth cohort (n=7401). Behaviours were ascertained by questionnaire at age 45 years. CMDs (depression, anxiety, panic, phobia) were assessed using the Clinical Interview Schedule-Revised at 45 years and depression using Mental Health Inventory-5 at 50 years. Results: Participants with CMDs at 45 years differed from others on some but not all vitamin D related behaviours. There were inverse, cross-sectional associations at 45 years of 25(OH)D with depression and panic, which persisted after adjustment for vitamin D related behaviours (OR=0.57, 95% CI: 0.40,0.81 and OR=0.33, 95% CI: 0.40,0.81, respectively). Association between 25(OH)D and subsequent (50 years) risk of depression was non-linear (p=0.01), with lower risk for participants with 25(OH)D between 50 and 85nmol/l compared with those with lower or higher concentrations. Conclusion: This study provides support for an association of low 25(OH)D concentrations with current and subsequent risk of depression in mid-adulthood.

    Original languageEnglish
    Pages (from-to)758-764
    Number of pages7
    JournalClinical Nutrition
    Issue number5
    Publication statusPublished or Issued - Oct 2013


    • 1958 British birth cohort
    • 25-Hydroxyvitamin D
    • Common mental disorders
    • Depressive symptoms
    • Mental health
    • Vitamin D

    ASJC Scopus subject areas

    • Nutrition and Dietetics
    • Critical Care and Intensive Care Medicine

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