Visual acuity and retinal function in infant monkeys fed long-chain PUFA

Brett G. Jeffrey, Drake C. Mitchell, Joseph R. Hibbeln, Robert A. Gibson, A. Lee Chedester, Norman Salem

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Previous randomized clinical trials suggest that supplementation of the human infant diet with up to 0.35% DHA may benefit visual development. The aim of the current study was to assess the impact of including arachidonic acid (AA) and a higher level of DHA in the postnatal monkey diet on visual development. Infant rhesus monkeys were fed either a control diet (2.0% α-linolenic acid as the sole n-3 FA) or a supplemented diet (1.0% DHA and 1.0% AA) from birth. Visual evoked potential acuity was measured at 3 mon of age. Rod and cone function were assessed in terms of parameters describing phototransduction. Electroretinogram (ERG) amplitudes and implicit times were recorded over a wide intensity range (-2.2 to 4.0 log scot td-sec) and assessed in terms of intensity response functions. Plasma DHA and AA were significantly increased (P < 0.001) in the diet-supplemented monkeys compared with the control monkeys. There was an approximately equal effect of diet for the rod phototransduction parameters, sensitivity, and capacitance but in the opposite directions. Diet-supplemented monkeys had significantly shorter b-wave implicit times at low retinal illuminances (<-0.6 log scot td-sec). There were no significant effects of diet for visual acuity or the other 23 ERG parameters measured. The results suggest that supplementation of the infant monkey diet with 1.0% DHA and 1.0% AA neither harms nor provides substantial benefit to the development of visual acuity or retinal function in the first four postnatal months.

LanguageEnglish
Pages839-848
Number of pages10
JournalLipids
Volume37
Issue number9
DOIs
Publication statusPublished - 1 Sep 2002

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

Cite this

Jeffrey, B. G., Mitchell, D. C., Hibbeln, J. R., Gibson, R. A., Lee Chedester, A., & Salem, N. (2002). Visual acuity and retinal function in infant monkeys fed long-chain PUFA. Lipids, 37(9), 839-848. https://doi.org/10.1007/s11745-002-0969-0
Jeffrey, Brett G. ; Mitchell, Drake C. ; Hibbeln, Joseph R. ; Gibson, Robert A. ; Lee Chedester, A. ; Salem, Norman. / Visual acuity and retinal function in infant monkeys fed long-chain PUFA. In: Lipids. 2002 ; Vol. 37, No. 9. pp. 839-848.
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Jeffrey, BG, Mitchell, DC, Hibbeln, JR, Gibson, RA, Lee Chedester, A & Salem, N 2002, 'Visual acuity and retinal function in infant monkeys fed long-chain PUFA', Lipids, vol. 37, no. 9, pp. 839-848. https://doi.org/10.1007/s11745-002-0969-0

Visual acuity and retinal function in infant monkeys fed long-chain PUFA. / Jeffrey, Brett G.; Mitchell, Drake C.; Hibbeln, Joseph R.; Gibson, Robert A.; Lee Chedester, A.; Salem, Norman.

In: Lipids, Vol. 37, No. 9, 01.09.2002, p. 839-848.

Research output: Contribution to journalArticle

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Jeffrey BG, Mitchell DC, Hibbeln JR, Gibson RA, Lee Chedester A, Salem N. Visual acuity and retinal function in infant monkeys fed long-chain PUFA. Lipids. 2002 Sep 1;37(9):839-848. https://doi.org/10.1007/s11745-002-0969-0