Using Wolbachia-based release for suppression of Aedes mosquitoes: Insights from genetic data and population simulations

Gordana Rašic', Nancy M. Endersby, Craig Williams, Ary A. Hoffmann

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A novel strategy for suppressing disease transmission by Aedes aegypti, the main vector of dengue, uses releases of mosquitoes infected with the bacterium Wolbachia pipientis. Wolbachia are currently released to interfere with viral transmission, but there is also potential to use strains in mosquito suppression and elimination programs via the deleterious effects of the bacterium on the host. Mosquito suppression depends on target areas being relatively isolated to prevent reinvasion and on local climatic conditions. Here we explored the opportunity for suppression of A. aegypti in central Queensland, Australia, by using microsatellite data and simulations based on CIMSiM models of local weather conditions and breeding container data. Our results indicate that Wolbachia-induced extinctions in central Queensland are possible, although they may eventually be compromised by ongoing mosquito migration between towns until these sources are also suppressed. The results highlight a novel use of deleterious Wolbachia infections to achieve ecological as well as disease-related endpoints.

LanguageEnglish
Pages1226-1234
Number of pages9
JournalEcological Applications
Volume24
Issue number5
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Keywords

  • Aedes aegypti
  • Breeding containers
  • CIMSiM
  • Genetic isolation
  • Local climatic conditions
  • Microsatellites
  • Population suppression/extinction
  • Wolbachia

ASJC Scopus subject areas

  • Ecology

Cite this

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abstract = "A novel strategy for suppressing disease transmission by Aedes aegypti, the main vector of dengue, uses releases of mosquitoes infected with the bacterium Wolbachia pipientis. Wolbachia are currently released to interfere with viral transmission, but there is also potential to use strains in mosquito suppression and elimination programs via the deleterious effects of the bacterium on the host. Mosquito suppression depends on target areas being relatively isolated to prevent reinvasion and on local climatic conditions. Here we explored the opportunity for suppression of A. aegypti in central Queensland, Australia, by using microsatellite data and simulations based on CIMSiM models of local weather conditions and breeding container data. Our results indicate that Wolbachia-induced extinctions in central Queensland are possible, although they may eventually be compromised by ongoing mosquito migration between towns until these sources are also suppressed. The results highlight a novel use of deleterious Wolbachia infections to achieve ecological as well as disease-related endpoints.",
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Using Wolbachia-based release for suppression of Aedes mosquitoes : Insights from genetic data and population simulations. / Rašic', Gordana; Endersby, Nancy M.; Williams, Craig; Hoffmann, Ary A.

In: Ecological Applications, Vol. 24, No. 5, 01.01.2014, p. 1226-1234.

Research output: Contribution to journalArticle

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