Tumour location and prognostic characteristics as determinants of survival of women with invasive breast cancer: South Australia hospital-based cancer registries, 1987-1998

P. G. Gill, S. N. Birrell, C. G. Luke, D. M. Roder

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Survivals from breast cancer varied by location of lesion (P<0.001), with 10-year survivals of 61% applying for central (n = 772), 73% for medial (n = 350), and 72% for lateral (n = 966) lesions. Univariate analyses of determinants of central locations indicated that the following were predictive: a more advanced TNM stage (P < 0.001); a larger tumour diameter (P = 0.002); a higher grade (P = 0.032); a negative oestrogen receptor status (P = 0.004); a negative progesterone receptor status (P = 0.004); and histological type (P = 0.011), with more of the lobular lesions being located centrally. Cox proportional hazards regression indicated that the relative risk (95% confidence limits) of case fatality for central, as opposed to other, lesions reduced from 1.46 (1.20, 1.78) to 1.16 (0.95, 1.41) when stage was added to the model, with no other factor having an additional conditioning effect. It is concluded that central lesions have worse outcomes, mostly due to their more advanced stages. Means of finding these tumours earlier should be investigated.

LanguageEnglish
Pages221-227
Number of pages7
JournalBreast
Volume11
Issue number3
DOIs
Publication statusPublished - 1 Jan 2002
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

Cite this

@article{d37a09531aab48e08432418755f656ac,
title = "Tumour location and prognostic characteristics as determinants of survival of women with invasive breast cancer: South Australia hospital-based cancer registries, 1987-1998",
abstract = "Survivals from breast cancer varied by location of lesion (P<0.001), with 10-year survivals of 61{\%} applying for central (n = 772), 73{\%} for medial (n = 350), and 72{\%} for lateral (n = 966) lesions. Univariate analyses of determinants of central locations indicated that the following were predictive: a more advanced TNM stage (P < 0.001); a larger tumour diameter (P = 0.002); a higher grade (P = 0.032); a negative oestrogen receptor status (P = 0.004); a negative progesterone receptor status (P = 0.004); and histological type (P = 0.011), with more of the lobular lesions being located centrally. Cox proportional hazards regression indicated that the relative risk (95{\%} confidence limits) of case fatality for central, as opposed to other, lesions reduced from 1.46 (1.20, 1.78) to 1.16 (0.95, 1.41) when stage was added to the model, with no other factor having an additional conditioning effect. It is concluded that central lesions have worse outcomes, mostly due to their more advanced stages. Means of finding these tumours earlier should be investigated.",
author = "Gill, {P. G.} and Birrell, {S. N.} and Luke, {C. G.} and Roder, {D. M.}",
year = "2002",
month = "1",
day = "1",
doi = "10.1054/brst.2001.0400",
language = "English",
volume = "11",
pages = "221--227",
journal = "Breast",
issn = "0960-9776",
publisher = "Churchill Livingstone",
number = "3",

}

Tumour location and prognostic characteristics as determinants of survival of women with invasive breast cancer : South Australia hospital-based cancer registries, 1987-1998. / Gill, P. G.; Birrell, S. N.; Luke, C. G.; Roder, D. M.

In: Breast, Vol. 11, No. 3, 01.01.2002, p. 221-227.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Tumour location and prognostic characteristics as determinants of survival of women with invasive breast cancer

T2 - Breast

AU - Gill, P. G.

AU - Birrell, S. N.

AU - Luke, C. G.

AU - Roder, D. M.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Survivals from breast cancer varied by location of lesion (P<0.001), with 10-year survivals of 61% applying for central (n = 772), 73% for medial (n = 350), and 72% for lateral (n = 966) lesions. Univariate analyses of determinants of central locations indicated that the following were predictive: a more advanced TNM stage (P < 0.001); a larger tumour diameter (P = 0.002); a higher grade (P = 0.032); a negative oestrogen receptor status (P = 0.004); a negative progesterone receptor status (P = 0.004); and histological type (P = 0.011), with more of the lobular lesions being located centrally. Cox proportional hazards regression indicated that the relative risk (95% confidence limits) of case fatality for central, as opposed to other, lesions reduced from 1.46 (1.20, 1.78) to 1.16 (0.95, 1.41) when stage was added to the model, with no other factor having an additional conditioning effect. It is concluded that central lesions have worse outcomes, mostly due to their more advanced stages. Means of finding these tumours earlier should be investigated.

AB - Survivals from breast cancer varied by location of lesion (P<0.001), with 10-year survivals of 61% applying for central (n = 772), 73% for medial (n = 350), and 72% for lateral (n = 966) lesions. Univariate analyses of determinants of central locations indicated that the following were predictive: a more advanced TNM stage (P < 0.001); a larger tumour diameter (P = 0.002); a higher grade (P = 0.032); a negative oestrogen receptor status (P = 0.004); a negative progesterone receptor status (P = 0.004); and histological type (P = 0.011), with more of the lobular lesions being located centrally. Cox proportional hazards regression indicated that the relative risk (95% confidence limits) of case fatality for central, as opposed to other, lesions reduced from 1.46 (1.20, 1.78) to 1.16 (0.95, 1.41) when stage was added to the model, with no other factor having an additional conditioning effect. It is concluded that central lesions have worse outcomes, mostly due to their more advanced stages. Means of finding these tumours earlier should be investigated.

UR - http://www.scopus.com/inward/record.url?scp=0036328154&partnerID=8YFLogxK

U2 - 10.1054/brst.2001.0400

DO - 10.1054/brst.2001.0400

M3 - Article

VL - 11

SP - 221

EP - 227

JO - Breast

JF - Breast

SN - 0960-9776

IS - 3

ER -