Tug of war in the haematopoietic stem cell niche: Do myeloma plasma cells compete for the HSC niche?

J. E. Noll, S. A. Williams, L. E. Purton, A. C W Zannettino

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

In the adult mammal, normal haematopoiesis occurs predominantly in the bone marrow, where primitive haematopoietic stem cells (HSC) and their progeny reside in specialised microenvironments. The bone marrow microenvironment contains specific anatomical areas (termed niches) that are highly specialised for the development of certain blood cell types, for example HSCs. The HSC niche provides important cell-cell interactions and signalling molecules that regulate HSC self-renewal and differentiation processes. These same signals and interactions are also important in the progression of haematological malignancies, such as multiple myeloma (MM). This review provides an overview of the bone marrow microenvironment and its involvement in normal, physiological HSC maintenance and plasma cell growth throughout MM disease progression.

LanguageEnglish
Article numbere91
JournalBlood cancer journal
Volume2
Issue number9
DOIs
Publication statusPublished - 1 Sep 2012

Keywords

  • bone microenvironment
  • haematopoietic stem cells
  • myeloma
  • niche

ASJC Scopus subject areas

  • Hematology
  • Oncology

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