Treatment and survival from breast cancer: The experience of patients at South Australian teaching hospitals between 1977 and 2003

Colin Luke, Grantley Gill, Stephen Birrell, Vlad Humeniuk, Martin Borg, Christos Karapetis, Bogda Koczwara, Ian Olver, Michael Penniment, Ken Pittman, Tim Price, David Walsh, Eng Kiat Yeoh, David Roder

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Rationale: Treatment guidelines recommend a more conservative surgical approach than mastectomy for early stage breast cancer and a stronger emphasis on adjuvant therapy. Registry data at South Australian teaching hospitals have been used to monitor survivals and treatment in relation to these guidelines. Aims and objectives: To use registry data to: (1) investigate trends in survival and treatment; and (2) compare treatment with guidelines. Methods: Registry data from three teaching hospitals were used to analyse trends in primary courses of treatment of breast cancers during 1977-2003 (n = 4671), using univariate analyses and multiple logistic regression. Disease-specific survivals were analysed using Kaplan-Meier product limit estimates and multivariable Cox proportional hazards regression. Results: The 5-year survival was 79.9%, but with a secular increase, reaching 83.6% in 1997-2003. The relative risk of death (95% confidence limits) was 0.74 (0.62, 0.88) for 1997-2003, compared with previous diagnoses, after adjusting for tumour node metastasis stage, grade, age and place of residence. Treatment changes included an increase in conservative surgery (as opposed to mastectomy) from 51.7% in 1977-1990 to 76.8% in 1997-2003 for stage I (P < 0.001) and from 31.1% to 52.2% across these periods for stage II (P < 0.001). Adjuvant radiotherapy also became more common (P < 0.001), with 20.6% of patients receiving this treatment in 1977-1990 compared with 60.7% in 1997-2003. Radiotherapy generally was more prevalent when conservative surgery was provided, although also relatively common in mastectomy patients when tumour diameters exceeded 50 mm or when there were four or more involved nodes. The proportion of patients receiving chemotherapy increased (P < 0.001), from 19.6% in 1977-1990 to 36.9% in 1997-2003, and the proportion having hormone therapy also increased (P < 0.001), from 34.3% to 59.4% between these periods. Conclusions: Survivals appear to be increasing and treatment trends are broadly consistent with guideline directions, and the earlier research on which these recommendations were based.

LanguageEnglish
Pages212-220
Number of pages9
JournalJournal of Evaluation in Clinical Practice
Volume13
Issue number2
DOIs
Publication statusPublished - 1 Apr 2007
Externally publishedYes

Keywords

  • Breast cancer
  • Registries
  • Survival trends
  • Treatment patterns

ASJC Scopus subject areas

  • Health Policy
  • Public Health, Environmental and Occupational Health

Cite this

Luke, Colin ; Gill, Grantley ; Birrell, Stephen ; Humeniuk, Vlad ; Borg, Martin ; Karapetis, Christos ; Koczwara, Bogda ; Olver, Ian ; Penniment, Michael ; Pittman, Ken ; Price, Tim ; Walsh, David ; Kiat Yeoh, Eng ; Roder, David. / Treatment and survival from breast cancer : The experience of patients at South Australian teaching hospitals between 1977 and 2003. In: Journal of Evaluation in Clinical Practice. 2007 ; Vol. 13, No. 2. pp. 212-220.
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abstract = "Rationale: Treatment guidelines recommend a more conservative surgical approach than mastectomy for early stage breast cancer and a stronger emphasis on adjuvant therapy. Registry data at South Australian teaching hospitals have been used to monitor survivals and treatment in relation to these guidelines. Aims and objectives: To use registry data to: (1) investigate trends in survival and treatment; and (2) compare treatment with guidelines. Methods: Registry data from three teaching hospitals were used to analyse trends in primary courses of treatment of breast cancers during 1977-2003 (n = 4671), using univariate analyses and multiple logistic regression. Disease-specific survivals were analysed using Kaplan-Meier product limit estimates and multivariable Cox proportional hazards regression. Results: The 5-year survival was 79.9{\%}, but with a secular increase, reaching 83.6{\%} in 1997-2003. The relative risk of death (95{\%} confidence limits) was 0.74 (0.62, 0.88) for 1997-2003, compared with previous diagnoses, after adjusting for tumour node metastasis stage, grade, age and place of residence. Treatment changes included an increase in conservative surgery (as opposed to mastectomy) from 51.7{\%} in 1977-1990 to 76.8{\%} in 1997-2003 for stage I (P < 0.001) and from 31.1{\%} to 52.2{\%} across these periods for stage II (P < 0.001). Adjuvant radiotherapy also became more common (P < 0.001), with 20.6{\%} of patients receiving this treatment in 1977-1990 compared with 60.7{\%} in 1997-2003. Radiotherapy generally was more prevalent when conservative surgery was provided, although also relatively common in mastectomy patients when tumour diameters exceeded 50 mm or when there were four or more involved nodes. The proportion of patients receiving chemotherapy increased (P < 0.001), from 19.6{\%} in 1977-1990 to 36.9{\%} in 1997-2003, and the proportion having hormone therapy also increased (P < 0.001), from 34.3{\%} to 59.4{\%} between these periods. Conclusions: Survivals appear to be increasing and treatment trends are broadly consistent with guideline directions, and the earlier research on which these recommendations were based.",
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Luke, C, Gill, G, Birrell, S, Humeniuk, V, Borg, M, Karapetis, C, Koczwara, B, Olver, I, Penniment, M, Pittman, K, Price, T, Walsh, D, Kiat Yeoh, E & Roder, D 2007, 'Treatment and survival from breast cancer: The experience of patients at South Australian teaching hospitals between 1977 and 2003', Journal of Evaluation in Clinical Practice, vol. 13, no. 2, pp. 212-220. https://doi.org/10.1111/j.1365-2753.2006.00678.x

Treatment and survival from breast cancer : The experience of patients at South Australian teaching hospitals between 1977 and 2003. / Luke, Colin; Gill, Grantley; Birrell, Stephen; Humeniuk, Vlad; Borg, Martin; Karapetis, Christos; Koczwara, Bogda; Olver, Ian; Penniment, Michael; Pittman, Ken; Price, Tim; Walsh, David; Kiat Yeoh, Eng; Roder, David.

In: Journal of Evaluation in Clinical Practice, Vol. 13, No. 2, 01.04.2007, p. 212-220.

Research output: Contribution to journalArticle

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T1 - Treatment and survival from breast cancer

T2 - Journal of Evaluation in Clinical Practice

AU - Luke, Colin

AU - Gill, Grantley

AU - Birrell, Stephen

AU - Humeniuk, Vlad

AU - Borg, Martin

AU - Karapetis, Christos

AU - Koczwara, Bogda

AU - Olver, Ian

AU - Penniment, Michael

AU - Pittman, Ken

AU - Price, Tim

AU - Walsh, David

AU - Kiat Yeoh, Eng

AU - Roder, David

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N2 - Rationale: Treatment guidelines recommend a more conservative surgical approach than mastectomy for early stage breast cancer and a stronger emphasis on adjuvant therapy. Registry data at South Australian teaching hospitals have been used to monitor survivals and treatment in relation to these guidelines. Aims and objectives: To use registry data to: (1) investigate trends in survival and treatment; and (2) compare treatment with guidelines. Methods: Registry data from three teaching hospitals were used to analyse trends in primary courses of treatment of breast cancers during 1977-2003 (n = 4671), using univariate analyses and multiple logistic regression. Disease-specific survivals were analysed using Kaplan-Meier product limit estimates and multivariable Cox proportional hazards regression. Results: The 5-year survival was 79.9%, but with a secular increase, reaching 83.6% in 1997-2003. The relative risk of death (95% confidence limits) was 0.74 (0.62, 0.88) for 1997-2003, compared with previous diagnoses, after adjusting for tumour node metastasis stage, grade, age and place of residence. Treatment changes included an increase in conservative surgery (as opposed to mastectomy) from 51.7% in 1977-1990 to 76.8% in 1997-2003 for stage I (P < 0.001) and from 31.1% to 52.2% across these periods for stage II (P < 0.001). Adjuvant radiotherapy also became more common (P < 0.001), with 20.6% of patients receiving this treatment in 1977-1990 compared with 60.7% in 1997-2003. Radiotherapy generally was more prevalent when conservative surgery was provided, although also relatively common in mastectomy patients when tumour diameters exceeded 50 mm or when there were four or more involved nodes. The proportion of patients receiving chemotherapy increased (P < 0.001), from 19.6% in 1977-1990 to 36.9% in 1997-2003, and the proportion having hormone therapy also increased (P < 0.001), from 34.3% to 59.4% between these periods. Conclusions: Survivals appear to be increasing and treatment trends are broadly consistent with guideline directions, and the earlier research on which these recommendations were based.

AB - Rationale: Treatment guidelines recommend a more conservative surgical approach than mastectomy for early stage breast cancer and a stronger emphasis on adjuvant therapy. Registry data at South Australian teaching hospitals have been used to monitor survivals and treatment in relation to these guidelines. Aims and objectives: To use registry data to: (1) investigate trends in survival and treatment; and (2) compare treatment with guidelines. Methods: Registry data from three teaching hospitals were used to analyse trends in primary courses of treatment of breast cancers during 1977-2003 (n = 4671), using univariate analyses and multiple logistic regression. Disease-specific survivals were analysed using Kaplan-Meier product limit estimates and multivariable Cox proportional hazards regression. Results: The 5-year survival was 79.9%, but with a secular increase, reaching 83.6% in 1997-2003. The relative risk of death (95% confidence limits) was 0.74 (0.62, 0.88) for 1997-2003, compared with previous diagnoses, after adjusting for tumour node metastasis stage, grade, age and place of residence. Treatment changes included an increase in conservative surgery (as opposed to mastectomy) from 51.7% in 1977-1990 to 76.8% in 1997-2003 for stage I (P < 0.001) and from 31.1% to 52.2% across these periods for stage II (P < 0.001). Adjuvant radiotherapy also became more common (P < 0.001), with 20.6% of patients receiving this treatment in 1977-1990 compared with 60.7% in 1997-2003. Radiotherapy generally was more prevalent when conservative surgery was provided, although also relatively common in mastectomy patients when tumour diameters exceeded 50 mm or when there were four or more involved nodes. The proportion of patients receiving chemotherapy increased (P < 0.001), from 19.6% in 1977-1990 to 36.9% in 1997-2003, and the proportion having hormone therapy also increased (P < 0.001), from 34.3% to 59.4% between these periods. Conclusions: Survivals appear to be increasing and treatment trends are broadly consistent with guideline directions, and the earlier research on which these recommendations were based.

KW - Breast cancer

KW - Registries

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KW - Treatment patterns

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