Transcriptional control of the core cell-death machinery

Sharad Kumar, Dimitrios Cakouros

Research output: Contribution to journalReview article

51 Citations (Scopus)


Developmental and physiological cues, as well as signals in response to cell damage, initiate a cell suicide program that is often referred to as apoptosis or programmed cell death (PCD). PCD is mediated by the core cell-death machinery consisting of proteins that mediate and control the activation of caspases - enzymes that dismantle cellular architecture during apoptosis. Because components of the caspase-activation apparatus are constitutively present in most cells, most studies during the last decade have focused on the posttranslational regulation of this preexisting machinery. However, accumulating evidence suggests that, in many contexts, transcriptional regulation also plays a crucial role in the activation of the physiological cell-death program.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalTrends in Biochemical Sciences
Issue number4
Publication statusPublished - 1 Apr 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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