Total synthesis of (+)-aureol

Kevin Kuan, Henry P. Pepper, Witold M. Bloch, Jonathan H. George

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A total synthesis of the marine sponge meroterpenoid (+)-aureol has been achieved in 12 steps (6% overall yield) from (+)-sclareolide. Key steps of the synthesis include a biosynthetically inspired sequence of 1,2-hydride and methyl shifts, and a biomimetic cycloetherification reaction.

Original languageEnglish
Pages (from-to)4710-4713
Number of pages4
JournalOrganic Letters
Volume14
Issue number18
DOIs
Publication statusPublished - 21 Sep 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Kuan, K., Pepper, H. P., Bloch, W. M., & George, J. H. (2012). Total synthesis of (+)-aureol. Organic Letters, 14(18), 4710-4713. https://doi.org/10.1021/ol301715u