Total synthesis of (+)-aureol

Kevin Kuan, Henry P. Pepper, Witold M. Bloch, Jonathan H. George

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

A total synthesis of the marine sponge meroterpenoid (+)-aureol has been achieved in 12 steps (6% overall yield) from (+)-sclareolide. Key steps of the synthesis include a biosynthetically inspired sequence of 1,2-hydride and methyl shifts, and a biomimetic cycloetherification reaction.

Original languageEnglish
Pages (from-to)4710-4713
Number of pages4
JournalOrganic Letters
Volume14
Issue number18
DOIs
Publication statusPublished - 21 Sep 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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