Timing of protein ingestion relative to resistance exercise training does not influence body composition, energy expenditure, glycaemic control or cardiometabolic risk factors in a hypocaloric, high protein diet in patients with type 2 diabetes

T. P. Wycherley, M. Noakes, P. M. Clifton, X. Cleanthous, J. B. Keogh, Grant D. Brinkworth

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Abstract

Aim: To investigate timing of protein ingestion relative to resistance exercise training (RT) on body composition, cardiometabolic risk factors, glycaemic control and resting energy expenditure (REE) during weight loss on a high-protein (HP) diet in overweight and obese patients with type 2 diabetes (T2DM). Methods: Thirty-four men/women with T2DM (age 57 ± 7 years and body mass index 34.9 ± 4.2 kg m-2) were randomly assigned to the ingestion of a HP meal (860 kJ, 21 g protein, 0.7 g fat, 29.6 g carbohydrate) either immediately prior to RT or at least 2 h following RT. All participants followed a 16-week, energy-restricted (6-7 MJ day-1), HP diet (carbohydrate protein fat 43 33 22) and participated in supervised RT (3 day week-1). Outcomes were assessed pre- and postintervention at 16 weeks. Results: There was an overall reduction in bodyweight (-11.9 ± 6.1 kg), fat mass (-10.0 ± 4.4 kg), fat-free mass (-1.9 ± 3.1 kg), waist circumference (-12.1 ± 5.3 cm), REE (-742 ± 624 kJ day-1), glucose (-1.9 ± 1.7 mmol l-1), insulin (-6.1 ± 6.7 mU l-1) and glycosylated haemoglobin (-1.1 ± 0.1%), p - 0.01 time for all variables, with no difference between groups (p ≥ 0.41 group effect). Strength improved and cardiometabolic risk factors were reduced similarly in both groups; single repetition maximum chest press 11.0 ± 8.7 kg, single repetition maximum lat pull down 9.9 ± 6.0 kg, total cholesterol -0.6 ± 0.5 mmol l-1, high-density lipoprotein cholesterol -0.1 ± 0.2 mmol l-1, low-density lipoprotein cholesterol -0.3 ± 0.5 mmol l-1, triglycerides -0.6 ± 0.7 mmol l-1, blood pressure (systolic/diastolic) -13 ± 10/-7 ± 7 mmHg (p ≤ 0.04 time effect, p ≥ 0.24 group effect). Conclusion: A HP, energy-restricted diet with RT was effective in improving glycaemic control, body composition, strength and cardiometabolic risk factors in overweight/obese patients with T2DM irrespective of altering the timing of protein ingestion relative to RT.

Original languageEnglish
Pages (from-to)1097-1105
Number of pages9
JournalDiabetes, Obesity and Metabolism
Volume12
Issue number12
DOIs
Publication statusPublished - 1 Jan 2010
Externally publishedYes

Keywords

  • Body composition
  • Clinical trials
  • Weight loss therapy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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