TY - JOUR
T1 - Time to pregnancy after a previous miscarriage in subfertile couples
AU - Cox, Tessa
AU - van der Steeg, Jan Willem
AU - Steures, Pieternel
AU - Hompes, Peter G A
AU - van der Veen, Fulco
AU - Eijkemans, Marinus J C
AU - Schagen van Leeuwen, Jules H.
AU - Renckens, Cees
AU - Bossuyt, Patrick M M
AU - Mol, Ben W J
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Objective: To assess the time to spontaneous ongoing pregnancy after a previous miscarriage in subfertile couples. Design: A prospective cohort study. Setting: The study was conducted in 38 fertility centers in the Netherlands. Patient(s): Subfertile couples who miscarried after completing their basic fertility work-up. Intervention(s): Expectant management after a miscarriage. Main Outcome Measure(s): Spontaneous ongoing pregnancy. Result(s): We included 5,663 subfertile couples, of which 1,098 (19%) conceived spontaneously. Among these 1,098 couples, 199 (18%) miscarried and these couples were included in the present study. Follow-up was completed for 171 couples, of which 95 conceived again within 24 months of follow-up. Of these 95 pregnancies, 86 (91%) were ongoing. The cumulative spontaneous ongoing pregnancy rate (PR) after 24 months was 70% (95% confidence interval [CI] 59%-81%). Conclusion(s): Subfertile couples, who experience a treatment-independent pregnancy resulting in a miscarriage, have very good prospects of a spontaneous ongoing pregnancy in the near future. This information is useful in counseling couples who had a miscarriage after a previous period of subfertility.
AB - Objective: To assess the time to spontaneous ongoing pregnancy after a previous miscarriage in subfertile couples. Design: A prospective cohort study. Setting: The study was conducted in 38 fertility centers in the Netherlands. Patient(s): Subfertile couples who miscarried after completing their basic fertility work-up. Intervention(s): Expectant management after a miscarriage. Main Outcome Measure(s): Spontaneous ongoing pregnancy. Result(s): We included 5,663 subfertile couples, of which 1,098 (19%) conceived spontaneously. Among these 1,098 couples, 199 (18%) miscarried and these couples were included in the present study. Follow-up was completed for 171 couples, of which 95 conceived again within 24 months of follow-up. Of these 95 pregnancies, 86 (91%) were ongoing. The cumulative spontaneous ongoing pregnancy rate (PR) after 24 months was 70% (95% confidence interval [CI] 59%-81%). Conclusion(s): Subfertile couples, who experience a treatment-independent pregnancy resulting in a miscarriage, have very good prospects of a spontaneous ongoing pregnancy in the near future. This information is useful in counseling couples who had a miscarriage after a previous period of subfertility.
KW - Subfertility
KW - miscarriage
KW - ongoing pregnancy
UR - http://www.scopus.com/inward/record.url?scp=77953699258&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2009.03.082
DO - 10.1016/j.fertnstert.2009.03.082
M3 - Article
VL - 94
SP - 485
EP - 488
JO - Fertility and Sterility
T2 - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 2
ER -