Three siblings with self-resolving congenital hyperthyrotropinaemia secondary to thyrotropin receptor blocking antibodies

Peter Azzopardi, Mike Forrester, Sarah Ehtisham

Research output: Contribution to journalArticle

Abstract

Thyrotropin receptor blocking antibodies are a rare cause of hyperthyrotropinaemia and more rarely of congenital hypothyroidism. We report a case of hyperthyrotropinaemia but normal thyroid hormone in the newborn of a mother with hypothyroidism treated with thyroxine. Two older siblings had similar high thyrotropin and normal thyroid function in the newborn period which did not require hormone treatment and resolved spontaneously. Demonstration of thyrotropin receptor antibodies in the child confirmed our diagnosis. Our case was not treated with thyroid replacement hormone and has remained biochemically euthyroid, with thyrotropin levels returning to normal over a period of months.

LanguageEnglish
Pages439-441
Number of pages3
JournalJournal of Paediatrics and Child Health
Volume46
Issue number7-8
DOIs
Publication statusPublished - 1 Jul 2010

Keywords

  • congenital hypothyroidism
  • neonatal thyroid screening
  • thyrotropin receptor antibody

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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Three siblings with self-resolving congenital hyperthyrotropinaemia secondary to thyrotropin receptor blocking antibodies. / Azzopardi, Peter; Forrester, Mike; Ehtisham, Sarah.

In: Journal of Paediatrics and Child Health, Vol. 46, No. 7-8, 01.07.2010, p. 439-441.

Research output: Contribution to journalArticle

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