The value of chromosomal analysis in oligozoospermic men

Çarcia Stegen, Minouche M E Van Rumste, Ben Willem J Mol, Carolien A M Koks

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To determine the prevalence of chromosomal abnormalities in relation to sperm concentration in subfertile oligozoospermic men. Design: Retrospective cohort study. Setting: Two teaching hospitals. Patient(s): We retrospectively studied all men who received chromosomal analysis prior to intracytoplasmic sperm injection (ICSI) treatment from 2000 to 2010 in two teaching hospitals. Intervention(s): None. Main Outcome Measure(s): The results of chromosomal analysis and semen analysis were recorded. The frequency of abnormal karyotypes was analyzed in relation to the sperm concentration, categorized as extreme oligozoospermia (>0 to ≤1 million/mL), severe oligozoospermia (>1 to ≤5 million/mL), moderate oligozoospermia (>5 to ≤20 million/mL), or normospermia (>20 million/mL). Result(s): Among 582 male ICSI candidates, the rates of abnormal karyotypes were 1.2% (2/162), 2.2% (5/227), and 1.5% (2/130) for men with extreme, severe, and moderate oligozoospermia, respectively. No abnormalities were present in normospermic men. Conclusion(s): The risk of conceiving a viable child with unbalanced structural chromosomal abnormalities in men with oligozoospermia may not justify karyotyping.

LanguageEnglish
Pages1438-1442
Number of pages5
JournalFertility and Sterility
Volume98
Issue number6
DOIs
Publication statusPublished - Dec 2012

Keywords

  • abnormal karyotype
  • Chromosomal analysis
  • ICSI
  • oligozoospermic men

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Stegen, Ç., Van Rumste, M. M. E., Mol, B. W. J., & Koks, C. A. M. (2012). The value of chromosomal analysis in oligozoospermic men. Fertility and Sterility, 98(6), 1438-1442. https://doi.org/10.1016/j.fertnstert.2012.08.005
Stegen, Çarcia ; Van Rumste, Minouche M E ; Mol, Ben Willem J ; Koks, Carolien A M. / The value of chromosomal analysis in oligozoospermic men. In: Fertility and Sterility. 2012 ; Vol. 98, No. 6. pp. 1438-1442.
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Stegen, Ç, Van Rumste, MME, Mol, BWJ & Koks, CAM 2012, 'The value of chromosomal analysis in oligozoospermic men', Fertility and Sterility, vol. 98, no. 6, pp. 1438-1442. https://doi.org/10.1016/j.fertnstert.2012.08.005

The value of chromosomal analysis in oligozoospermic men. / Stegen, Çarcia; Van Rumste, Minouche M E; Mol, Ben Willem J; Koks, Carolien A M.

In: Fertility and Sterility, Vol. 98, No. 6, 12.2012, p. 1438-1442.

Research output: Contribution to journalArticle

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