The use of polymer-based nanoparticles and nanostructured materials in treatment and diagnosis of cardiovascular diseases: Recent advances and emerging designs

Yen Jen Wang, Mikael Larsson, Wei Ting Huang, Shih Hwa Chiou, Stephen J. Nicholls, Jui I. Chao, Dean Mo Liu

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

This review summarizes important advances in polymer-based nanotechnologies for the treatment and diagnosis of cardiovascular diseases, focusing on nanoparticles and nanostructured materials/devices. The current state of the art and design parameters are discussed with the aim of providing a source of information that can aid in the development of new treatments by bridging between materials development, preclinical, and clinical trials. This is highly relevant as cardiovascular diseases remain a leading cause of death worldwide and as current treatments burden the healthcare systems with great costs. Different strategies, from targeting theranostic nanocarriers, to dual-drug depot systems, injectable cell scaffolds, and LDL acceptors are treated. The review ends with a concluding outlook on the possibilities and challenges presented to polymer-based nanotechnologies in cardiovascular disease therapy.

LanguageEnglish
Pages153-178
Number of pages26
JournalProgress in Polymer Science
Volume57
DOIs
Publication statusPublished - 1 Jun 2016

Keywords

  • Cardiovascular diseases
  • Drug delivery
  • Nanoparticles
  • Nanostructured
  • Polymers
  • Theranostic

ASJC Scopus subject areas

  • Ceramics and Composites
  • Surfaces and Interfaces
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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