Abstract
Four decades after the first isolation and characterization of clonogenic bone marrow stromal cells or mesenchymal stem cells (MSC) in the laboratory of Dr. Alexander Friedenstien, the therapeutic application of their progeny following ex vivo expansion are only now starting to be realized in the clinic. The multipotency, paracrine effects, and immune-modulatory properties of MSC present them as an ideal stem cell candidate for tissue engineering and regenerative medicine. In recent years it has come to light that MSC encompass plasticity that extends beyond the conventional bone, adipose, cartilage, and other skeletal structures, and has expanded to the differentiation of liver, kidney, muscle, skin, neural, and cardiac cell lineages. This review will specifically focus on the skeletal regenerative capacity of bone marrow derived MSC alone or in combination with growth factors, biocompatible scaffolds, and following genetic modification.
| Language | English |
|---|---|
| Pages | 237-245 |
| Number of pages | 9 |
| Journal | Journal of Cellular Physiology |
| Volume | 218 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Feb 2009 |
ASJC Scopus subject areas
- Medicine(all)
- Physiology
- Clinical Biochemistry
- Cell Biology
Cite this
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The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair. / Arthur, Agnieszka; Zannettino, Andrew; Gronthos, Stan.
In: Journal of Cellular Physiology, Vol. 218, No. 2, 01.02.2009, p. 237-245.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair
AU - Arthur, Agnieszka
AU - Zannettino, Andrew
AU - Gronthos, Stan
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Four decades after the first isolation and characterization of clonogenic bone marrow stromal cells or mesenchymal stem cells (MSC) in the laboratory of Dr. Alexander Friedenstien, the therapeutic application of their progeny following ex vivo expansion are only now starting to be realized in the clinic. The multipotency, paracrine effects, and immune-modulatory properties of MSC present them as an ideal stem cell candidate for tissue engineering and regenerative medicine. In recent years it has come to light that MSC encompass plasticity that extends beyond the conventional bone, adipose, cartilage, and other skeletal structures, and has expanded to the differentiation of liver, kidney, muscle, skin, neural, and cardiac cell lineages. This review will specifically focus on the skeletal regenerative capacity of bone marrow derived MSC alone or in combination with growth factors, biocompatible scaffolds, and following genetic modification.
AB - Four decades after the first isolation and characterization of clonogenic bone marrow stromal cells or mesenchymal stem cells (MSC) in the laboratory of Dr. Alexander Friedenstien, the therapeutic application of their progeny following ex vivo expansion are only now starting to be realized in the clinic. The multipotency, paracrine effects, and immune-modulatory properties of MSC present them as an ideal stem cell candidate for tissue engineering and regenerative medicine. In recent years it has come to light that MSC encompass plasticity that extends beyond the conventional bone, adipose, cartilage, and other skeletal structures, and has expanded to the differentiation of liver, kidney, muscle, skin, neural, and cardiac cell lineages. This review will specifically focus on the skeletal regenerative capacity of bone marrow derived MSC alone or in combination with growth factors, biocompatible scaffolds, and following genetic modification.
UR - http://www.scopus.com/inward/record.url?scp=58149265734&partnerID=8YFLogxK
U2 - 10.1002/jcp.21592
DO - 10.1002/jcp.21592
M3 - Short survey
VL - 218
SP - 237
EP - 245
JO - Journal of Cellular Physiology
T2 - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
SN - 0021-9541
IS - 2
ER -