The role of n-6 polyunsaturated fat in stable asthmatics

A. Morris, M. Noakes, P. M. Clifton

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We investigated in a clinical setting whether increased intake of linoleic acid alters respiratory function in 26 mild asthmatics. Subjects completed a 16-week-dietary intervention comprising 8 weeks eating an enriched n-6 polyunsaturated fat diet (9.2 % energy from linoleic acid) and consuming either a high monounsaturated or saturated fat diet in a random cross-over resign for 8 weeks. Neither FEV1 nor PC20 values changed significantly after increased linoleic acid consumption when compared with the other diets. Increased consumption of linoleic acid caused a 20% rise (p ≤ 0.01) in plasma linoleic acid, a 38% decrease (p ≤ 0.01) in plasma eicosapentaenoic acid, but no change in arachidonic acid. There were no changes in symptom scores or bronchodilator use.

LanguageEnglish
Pages311-319
Number of pages9
JournalJournal of Asthma
Volume38
Issue number4
DOIs
Publication statusPublished - 24 Jul 2001
Externally publishedYes

Keywords

  • Asthma
  • Bronchial provocation
  • Linoleic acid

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Morris, A. ; Noakes, M. ; Clifton, P. M. / The role of n-6 polyunsaturated fat in stable asthmatics. In: Journal of Asthma. 2001 ; Vol. 38, No. 4. pp. 311-319.
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Morris, A, Noakes, M & Clifton, PM 2001, 'The role of n-6 polyunsaturated fat in stable asthmatics', Journal of Asthma, vol. 38, no. 4, pp. 311-319. https://doi.org/10.1081/JAS-100002297

The role of n-6 polyunsaturated fat in stable asthmatics. / Morris, A.; Noakes, M.; Clifton, P. M.

In: Journal of Asthma, Vol. 38, No. 4, 24.07.2001, p. 311-319.

Research output: Contribution to journalArticle

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