The role of microRNAs in bovine infection and immunity

Nathan Lawless, Peter Vegh, Cliona O'Farrelly, David J. Lynn

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are recognized as critical regulators of immune gene expression during infection. Many immunologically significant human miRNAs have been found to be conserved in agriculturally important species, including cattle. Discovering how bovine miRNAs mediate the immune defense during infection is critical to understanding the etiology of the most prevalent bovine diseases. Here, we review current knowledge of miRNAs in the bovine genome, and discuss the advances in understanding of miRNAs as regulators of immune cell function, and bovine immune response activation, regulation, and resolution. Finally, we consider the future perspectives on miRNAs in bovine viral disease, their role as potential biomarkers and in therapy.

Original languageEnglish
Article number611
JournalFrontiers in Immunology
Volume5
Issue numberNOV
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Bos taurus
  • Bovine
  • Immune system
  • miRNA
  • microRNA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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