The role of high-density lipoproteins in the regulation of angiogenesis

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Angiogenesis is important for postnatal physiological processes including tissue neovascularization in response to an ischaemic injury. Conversely, uncontrolled inflammatory-driven angiogenesis can accelerate atherosclerotic plaque and tumour growth. Angiogenesis-associated diseases are highly prevalent globally, with cardiovascular-related disorders and cancer being the leading causes of mortality worldwide. A vast amount of research has been conducted on the vasculoprotective effects of high-density lipoproteins (HDLs) and while current HDL-raising therapies to date have not yielded the desired benefits clinically, its role in angiogenesis is yet to be fully elucidated. Epidemiological studies report positive correlations between elevated HDL levels and improved prognosis in both ischaemia- and inflammatory-driven pathologies, in which angiogenesis plays a key role. This review focuses on current evidence from epidemiological and prospective studies, coupled with animal models and mechanistic studies that highlight the ability of HDL to conditionally regulate angiogenesis.

LanguageEnglish
Pages184-193
Number of pages10
JournalCardiovascular Research
Volume106
Issue number2
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Angiogenesis
  • High-density lipoprotein
  • Inflammation
  • Ischaemia

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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