The role of Eph/ephrin molecules in stromal–hematopoietic interactions

Thao M. Nguyen, Agnieszka Arthur, Stan Gronthos

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Bone marrow mesenchymal stromal/stem cells (BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrin ligands. Eph/ephrin interactions are thought to mediate cross-talk between BMSC and different hematopoietic cell populations to influence cell development, migration and function. This review summarizes Eph/ephrin interactions in the regulation of BMSC communication with hematopoietic stem/progenitor cells and discusses Eph/ephrin-targeted therapeutic strategies that are currently being pursued for various hematotological malignancies.

LanguageEnglish
Pages145-154
Number of pages10
JournalInternational Journal of Hematology
Volume103
Issue number2
DOIs
Publication statusPublished - 1 Feb 2016

Keywords

  • Bone marrow mesenchymal/stem cells
  • Eph receptors
  • Ephrin ligands
  • Haematopoietic stem cells niche
  • Stromal cells

ASJC Scopus subject areas

  • Hematology

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