The role of cationic antimicrobial peptides in innate host defences

Robert E.W. Hancock, Gill Diamond

Research output: Contribution to journalReview articlepeer-review

922 Citations (Scopus)


Cationic antimicrobial peptides are found in all living species. A single animal can contain >24 different antimicrobial peptides, which fall into four structural classes. These peptides are produced in large quantities at sites of infection and/or inflammation and can have broad-spectrum antibacterial, antifungal, antiviral, antiprotozoan and antisepsis properties. In addition, they interact directly with host cells to modulate the inflammatory process and innate defences.

Original languageEnglish
Pages (from-to)402-410
Number of pages9
JournalTrends in Microbiology
Issue number9
Publication statusPublished or Issued - 1 Sep 2000
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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