The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count

Simone L. Broer, B. W J Mol, Dave Hendriks, F. J M Broekmans

Research output: Contribution to journalArticle

335 Citations (Scopus)

Abstract

Objective: To assess the value of antimullerian hormone (AMH) as a test to predict poor ovarian response and pregnancy occurrence after IVF and to compare it with the performance of the antral follicle count (AFC). Design: A systematic review of existing literature and a meta-analysis were carried out. After a comprehensive search, studies were included if 2 × 2 tables for outcomes poor response and pregnancy in IVF patients in relation to AMH or AFC could be constructed. Setting: Academic referral center for tertiary care. Patient(s): Cases indicated for IVF. Intervention(s): None. Main Outcome Measure(s): Poor response and nonpregnancy after IVF. Result(s): A total of 13 studies were found reporting on AMH and 17 on AFC. Because of heterogeneity among studies, calculation of a summary point estimate for sensitivity and specificity was not possible. However, for both tests summary receiver operating characteristic curves for the outcome measures poor response and nonpregnancy could be estimated and compared. The curves for the prediction of poor response indicated no significant difference between the performances of AMH and AFC. For the prediction of nonpregnancy, poor performance for both AMH and AFC was found. Conclusion(s): In this meta-analysis it was shown that AMH has at least the same level of accuracy and clinical value for the prediction of poor response and nonpregnancy as AFC.

LanguageEnglish
Pages705-714
Number of pages10
JournalFertility and Sterility
Volume91
Issue number3
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Antimullerian hormone
  • antral follicle count
  • IVF
  • meta-analysis
  • poor response
  • pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Broer, Simone L. ; Mol, B. W J ; Hendriks, Dave ; Broekmans, F. J M. / The role of antimullerian hormone in prediction of outcome after IVF : comparison with the antral follicle count. In: Fertility and Sterility. 2009 ; Vol. 91, No. 3. pp. 705-714.
@article{a4a936e0eb8342fdad1da32438b9c0d0,
title = "The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count",
abstract = "Objective: To assess the value of antimullerian hormone (AMH) as a test to predict poor ovarian response and pregnancy occurrence after IVF and to compare it with the performance of the antral follicle count (AFC). Design: A systematic review of existing literature and a meta-analysis were carried out. After a comprehensive search, studies were included if 2 × 2 tables for outcomes poor response and pregnancy in IVF patients in relation to AMH or AFC could be constructed. Setting: Academic referral center for tertiary care. Patient(s): Cases indicated for IVF. Intervention(s): None. Main Outcome Measure(s): Poor response and nonpregnancy after IVF. Result(s): A total of 13 studies were found reporting on AMH and 17 on AFC. Because of heterogeneity among studies, calculation of a summary point estimate for sensitivity and specificity was not possible. However, for both tests summary receiver operating characteristic curves for the outcome measures poor response and nonpregnancy could be estimated and compared. The curves for the prediction of poor response indicated no significant difference between the performances of AMH and AFC. For the prediction of nonpregnancy, poor performance for both AMH and AFC was found. Conclusion(s): In this meta-analysis it was shown that AMH has at least the same level of accuracy and clinical value for the prediction of poor response and nonpregnancy as AFC.",
keywords = "Antimullerian hormone, antral follicle count, IVF, meta-analysis, poor response, pregnancy",
author = "Broer, {Simone L.} and Mol, {B. W J} and Dave Hendriks and Broekmans, {F. J M}",
year = "2009",
month = "3",
doi = "10.1016/j.fertnstert.2007.12.013",
language = "English",
volume = "91",
pages = "705--714",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "3",

}

The role of antimullerian hormone in prediction of outcome after IVF : comparison with the antral follicle count. / Broer, Simone L.; Mol, B. W J; Hendriks, Dave; Broekmans, F. J M.

In: Fertility and Sterility, Vol. 91, No. 3, 03.2009, p. 705-714.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The role of antimullerian hormone in prediction of outcome after IVF

T2 - Fertility and Sterility

AU - Broer, Simone L.

AU - Mol, B. W J

AU - Hendriks, Dave

AU - Broekmans, F. J M

PY - 2009/3

Y1 - 2009/3

N2 - Objective: To assess the value of antimullerian hormone (AMH) as a test to predict poor ovarian response and pregnancy occurrence after IVF and to compare it with the performance of the antral follicle count (AFC). Design: A systematic review of existing literature and a meta-analysis were carried out. After a comprehensive search, studies were included if 2 × 2 tables for outcomes poor response and pregnancy in IVF patients in relation to AMH or AFC could be constructed. Setting: Academic referral center for tertiary care. Patient(s): Cases indicated for IVF. Intervention(s): None. Main Outcome Measure(s): Poor response and nonpregnancy after IVF. Result(s): A total of 13 studies were found reporting on AMH and 17 on AFC. Because of heterogeneity among studies, calculation of a summary point estimate for sensitivity and specificity was not possible. However, for both tests summary receiver operating characteristic curves for the outcome measures poor response and nonpregnancy could be estimated and compared. The curves for the prediction of poor response indicated no significant difference between the performances of AMH and AFC. For the prediction of nonpregnancy, poor performance for both AMH and AFC was found. Conclusion(s): In this meta-analysis it was shown that AMH has at least the same level of accuracy and clinical value for the prediction of poor response and nonpregnancy as AFC.

AB - Objective: To assess the value of antimullerian hormone (AMH) as a test to predict poor ovarian response and pregnancy occurrence after IVF and to compare it with the performance of the antral follicle count (AFC). Design: A systematic review of existing literature and a meta-analysis were carried out. After a comprehensive search, studies were included if 2 × 2 tables for outcomes poor response and pregnancy in IVF patients in relation to AMH or AFC could be constructed. Setting: Academic referral center for tertiary care. Patient(s): Cases indicated for IVF. Intervention(s): None. Main Outcome Measure(s): Poor response and nonpregnancy after IVF. Result(s): A total of 13 studies were found reporting on AMH and 17 on AFC. Because of heterogeneity among studies, calculation of a summary point estimate for sensitivity and specificity was not possible. However, for both tests summary receiver operating characteristic curves for the outcome measures poor response and nonpregnancy could be estimated and compared. The curves for the prediction of poor response indicated no significant difference between the performances of AMH and AFC. For the prediction of nonpregnancy, poor performance for both AMH and AFC was found. Conclusion(s): In this meta-analysis it was shown that AMH has at least the same level of accuracy and clinical value for the prediction of poor response and nonpregnancy as AFC.

KW - Antimullerian hormone

KW - antral follicle count

KW - IVF

KW - meta-analysis

KW - poor response

KW - pregnancy

UR - http://www.scopus.com/inward/record.url?scp=61349180236&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2007.12.013

DO - 10.1016/j.fertnstert.2007.12.013

M3 - Article

VL - 91

SP - 705

EP - 714

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 3

ER -