The role of antimullerian hormone in prediction of outcome after IVF: Comparison with the antral follicle count

Simone L. Broer, B. W J Mol, Dave Hendriks, F. J M Broekmans

Research output: Contribution to journalArticle

Abstract

Objective: To assess the value of antimullerian hormone (AMH) as a test to predict poor ovarian response and pregnancy occurrence after IVF and to compare it with the performance of the antral follicle count (AFC). Design: A systematic review of existing literature and a meta-analysis were carried out. After a comprehensive search, studies were included if 2 × 2 tables for outcomes poor response and pregnancy in IVF patients in relation to AMH or AFC could be constructed. Setting: Academic referral center for tertiary care. Patient(s): Cases indicated for IVF. Intervention(s): None. Main Outcome Measure(s): Poor response and nonpregnancy after IVF. Result(s): A total of 13 studies were found reporting on AMH and 17 on AFC. Because of heterogeneity among studies, calculation of a summary point estimate for sensitivity and speci?city was not possible. However, for both tests summary receiver operating characteristic curves for the outcome measures poor response and nonpregnancy could be estimated and compared. The curves for the prediction of poor response indicated no significant difference between the performances of AMH and AFC. For the prediction of nonpregnancy, poor performance for both AMH and AFC was found. Conclusion(s): In this meta-analysis it was shown that AMH has at least the same level of accuracy and clinical value for the prediction of poor response and nonpregnancy as AFC.

Translated title of the contributionThe role of antimullerian hormone in prediction of outcome after IVF: Comparison with the antral follicle count
LanguageSpanish
Pages259-270
Number of pages12
JournalRevista Iberoamericana de Fertilidad y Reproduccion Humana
Volume26
Issue number3
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Antimullerian hormone
  • Antral follicle count
  • IVF
  • Meta-analysis
  • Poor response
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

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title = "El papel de la harmona antim{\"u}leriana en la predicci{\'o}n de los resultados de FIV: Comparaci{\'o}n con el recuento de fol{\'i}culos antrales",
abstract = "Objective: To assess the value of antimullerian hormone (AMH) as a test to predict poor ovarian response and pregnancy occurrence after IVF and to compare it with the performance of the antral follicle count (AFC). Design: A systematic review of existing literature and a meta-analysis were carried out. After a comprehensive search, studies were included if 2 × 2 tables for outcomes poor response and pregnancy in IVF patients in relation to AMH or AFC could be constructed. Setting: Academic referral center for tertiary care. Patient(s): Cases indicated for IVF. Intervention(s): None. Main Outcome Measure(s): Poor response and nonpregnancy after IVF. Result(s): A total of 13 studies were found reporting on AMH and 17 on AFC. Because of heterogeneity among studies, calculation of a summary point estimate for sensitivity and speci?city was not possible. However, for both tests summary receiver operating characteristic curves for the outcome measures poor response and nonpregnancy could be estimated and compared. The curves for the prediction of poor response indicated no significant difference between the performances of AMH and AFC. For the prediction of nonpregnancy, poor performance for both AMH and AFC was found. Conclusion(s): In this meta-analysis it was shown that AMH has at least the same level of accuracy and clinical value for the prediction of poor response and nonpregnancy as AFC.",
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El papel de la harmona antimüleriana en la predicción de los resultados de FIV : Comparación con el recuento de folículos antrales. / Broer, Simone L.; Mol, B. W J; Hendriks, Dave; Broekmans, F. J M.

In: Revista Iberoamericana de Fertilidad y Reproduccion Humana, Vol. 26, No. 3, 2009, p. 259-270.

Research output: Contribution to journalArticle

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T2 - Revista Iberoamericana de Fertilidad y Reproduccion Humana

AU - Broer, Simone L.

AU - Mol, B. W J

AU - Hendriks, Dave

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AB - Objective: To assess the value of antimullerian hormone (AMH) as a test to predict poor ovarian response and pregnancy occurrence after IVF and to compare it with the performance of the antral follicle count (AFC). Design: A systematic review of existing literature and a meta-analysis were carried out. After a comprehensive search, studies were included if 2 × 2 tables for outcomes poor response and pregnancy in IVF patients in relation to AMH or AFC could be constructed. Setting: Academic referral center for tertiary care. Patient(s): Cases indicated for IVF. Intervention(s): None. Main Outcome Measure(s): Poor response and nonpregnancy after IVF. Result(s): A total of 13 studies were found reporting on AMH and 17 on AFC. Because of heterogeneity among studies, calculation of a summary point estimate for sensitivity and speci?city was not possible. However, for both tests summary receiver operating characteristic curves for the outcome measures poor response and nonpregnancy could be estimated and compared. The curves for the prediction of poor response indicated no significant difference between the performances of AMH and AFC. For the prediction of nonpregnancy, poor performance for both AMH and AFC was found. Conclusion(s): In this meta-analysis it was shown that AMH has at least the same level of accuracy and clinical value for the prediction of poor response and nonpregnancy as AFC.

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