The prognostic capacity of transvaginal hydrolaparoscopy to predict non-IVF conception

Mianne van Kessel, Rachel Tros, Jur Oosterhuis, Walter H. Kuchenbecker, Elly M. Vernooij, Marlies Y. Bongers, Ben Mol, Carolien A. Koks

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Transvaginal hydrolaparoscopy (THL) is performed to investigate tubal pathology in subfertile women. This retrospective multicentre cohort study investigated the results of THL and subsequent pregnancy rates. Between 2000 and 2011, 1033 subfertile women participated in the study. The primary outcome measure was intrauterine pregnancy, either after natural conception or after treatment with intrauterine insemination or ovulation induction. Cumulative intrauterine pregnancy rates were calculated using Kaplan–Meier analysis and fecundity rate ratios (FRR) were established. THL showed bilateral patent tubes in 83%, one-sided tubal occlusion in 12.4% and bilateral tubal occlusion in 4.6% of women. Cumulative intrauterine pregnancy rates after 36 months were 52% for women with bilateral patent tubes, 44% for one-sided tubal occlusion (FRR 1.04; 95% confidence interval [CI], 0.78 to 1.39) and 7% for bilateral tubal occlusion (FRR 0.13; 95% CI, 0.04 to 0.43). Endometriosis was diagnosed in 6.4%, and adhesions in 9.1%, while 3.9% of women had both. Corresponding FRR were 0.73 (95% CI, 0.49 to 1.09), 0.68 (95% CI, 0.46 to 1.02) and 0.42 (95% CI, 0.20 to 0.84). In conclusion, women with bilateral tubal occlusion or a combination of endometriosis and adhesions found on THL significantly reduced chances of natural conception.

LanguageEnglish
Pages552-559
Number of pages8
JournalReproductive BioMedicine Online
Volume36
Issue number5
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • Fecundity rate ratio
  • Infertility
  • Prognostic capacity
  • Transvaginal hydrolaparoscopy
  • Tubal pathology

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology

Cite this

van Kessel, M., Tros, R., Oosterhuis, J., Kuchenbecker, W. H., Vernooij, E. M., Bongers, M. Y., ... Koks, C. A. (2018). The prognostic capacity of transvaginal hydrolaparoscopy to predict non-IVF conception. Reproductive BioMedicine Online, 36(5), 552-559. https://doi.org/10.1016/j.rbmo.2018.01.012
van Kessel, Mianne ; Tros, Rachel ; Oosterhuis, Jur ; Kuchenbecker, Walter H. ; Vernooij, Elly M. ; Bongers, Marlies Y. ; Mol, Ben ; Koks, Carolien A. / The prognostic capacity of transvaginal hydrolaparoscopy to predict non-IVF conception. In: Reproductive BioMedicine Online. 2018 ; Vol. 36, No. 5. pp. 552-559.
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abstract = "Transvaginal hydrolaparoscopy (THL) is performed to investigate tubal pathology in subfertile women. This retrospective multicentre cohort study investigated the results of THL and subsequent pregnancy rates. Between 2000 and 2011, 1033 subfertile women participated in the study. The primary outcome measure was intrauterine pregnancy, either after natural conception or after treatment with intrauterine insemination or ovulation induction. Cumulative intrauterine pregnancy rates were calculated using Kaplan–Meier analysis and fecundity rate ratios (FRR) were established. THL showed bilateral patent tubes in 83{\%}, one-sided tubal occlusion in 12.4{\%} and bilateral tubal occlusion in 4.6{\%} of women. Cumulative intrauterine pregnancy rates after 36 months were 52{\%} for women with bilateral patent tubes, 44{\%} for one-sided tubal occlusion (FRR 1.04; 95{\%} confidence interval [CI], 0.78 to 1.39) and 7{\%} for bilateral tubal occlusion (FRR 0.13; 95{\%} CI, 0.04 to 0.43). Endometriosis was diagnosed in 6.4{\%}, and adhesions in 9.1{\%}, while 3.9{\%} of women had both. Corresponding FRR were 0.73 (95{\%} CI, 0.49 to 1.09), 0.68 (95{\%} CI, 0.46 to 1.02) and 0.42 (95{\%} CI, 0.20 to 0.84). In conclusion, women with bilateral tubal occlusion or a combination of endometriosis and adhesions found on THL significantly reduced chances of natural conception.",
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van Kessel, M, Tros, R, Oosterhuis, J, Kuchenbecker, WH, Vernooij, EM, Bongers, MY, Mol, B & Koks, CA 2018, 'The prognostic capacity of transvaginal hydrolaparoscopy to predict non-IVF conception', Reproductive BioMedicine Online, vol. 36, no. 5, pp. 552-559. https://doi.org/10.1016/j.rbmo.2018.01.012

The prognostic capacity of transvaginal hydrolaparoscopy to predict non-IVF conception. / van Kessel, Mianne; Tros, Rachel; Oosterhuis, Jur; Kuchenbecker, Walter H.; Vernooij, Elly M.; Bongers, Marlies Y.; Mol, Ben; Koks, Carolien A.

In: Reproductive BioMedicine Online, Vol. 36, No. 5, 01.05.2018, p. 552-559.

Research output: Contribution to journalArticle

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T1 - The prognostic capacity of transvaginal hydrolaparoscopy to predict non-IVF conception

AU - van Kessel, Mianne

AU - Tros, Rachel

AU - Oosterhuis, Jur

AU - Kuchenbecker, Walter H.

AU - Vernooij, Elly M.

AU - Bongers, Marlies Y.

AU - Mol, Ben

AU - Koks, Carolien A.

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N2 - Transvaginal hydrolaparoscopy (THL) is performed to investigate tubal pathology in subfertile women. This retrospective multicentre cohort study investigated the results of THL and subsequent pregnancy rates. Between 2000 and 2011, 1033 subfertile women participated in the study. The primary outcome measure was intrauterine pregnancy, either after natural conception or after treatment with intrauterine insemination or ovulation induction. Cumulative intrauterine pregnancy rates were calculated using Kaplan–Meier analysis and fecundity rate ratios (FRR) were established. THL showed bilateral patent tubes in 83%, one-sided tubal occlusion in 12.4% and bilateral tubal occlusion in 4.6% of women. Cumulative intrauterine pregnancy rates after 36 months were 52% for women with bilateral patent tubes, 44% for one-sided tubal occlusion (FRR 1.04; 95% confidence interval [CI], 0.78 to 1.39) and 7% for bilateral tubal occlusion (FRR 0.13; 95% CI, 0.04 to 0.43). Endometriosis was diagnosed in 6.4%, and adhesions in 9.1%, while 3.9% of women had both. Corresponding FRR were 0.73 (95% CI, 0.49 to 1.09), 0.68 (95% CI, 0.46 to 1.02) and 0.42 (95% CI, 0.20 to 0.84). In conclusion, women with bilateral tubal occlusion or a combination of endometriosis and adhesions found on THL significantly reduced chances of natural conception.

AB - Transvaginal hydrolaparoscopy (THL) is performed to investigate tubal pathology in subfertile women. This retrospective multicentre cohort study investigated the results of THL and subsequent pregnancy rates. Between 2000 and 2011, 1033 subfertile women participated in the study. The primary outcome measure was intrauterine pregnancy, either after natural conception or after treatment with intrauterine insemination or ovulation induction. Cumulative intrauterine pregnancy rates were calculated using Kaplan–Meier analysis and fecundity rate ratios (FRR) were established. THL showed bilateral patent tubes in 83%, one-sided tubal occlusion in 12.4% and bilateral tubal occlusion in 4.6% of women. Cumulative intrauterine pregnancy rates after 36 months were 52% for women with bilateral patent tubes, 44% for one-sided tubal occlusion (FRR 1.04; 95% confidence interval [CI], 0.78 to 1.39) and 7% for bilateral tubal occlusion (FRR 0.13; 95% CI, 0.04 to 0.43). Endometriosis was diagnosed in 6.4%, and adhesions in 9.1%, while 3.9% of women had both. Corresponding FRR were 0.73 (95% CI, 0.49 to 1.09), 0.68 (95% CI, 0.46 to 1.02) and 0.42 (95% CI, 0.20 to 0.84). In conclusion, women with bilateral tubal occlusion or a combination of endometriosis and adhesions found on THL significantly reduced chances of natural conception.

KW - Fecundity rate ratio

KW - Infertility

KW - Prognostic capacity

KW - Transvaginal hydrolaparoscopy

KW - Tubal pathology

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van Kessel M, Tros R, Oosterhuis J, Kuchenbecker WH, Vernooij EM, Bongers MY et al. The prognostic capacity of transvaginal hydrolaparoscopy to predict non-IVF conception. Reproductive BioMedicine Online. 2018 May 1;36(5):552-559. https://doi.org/10.1016/j.rbmo.2018.01.012