The Opisthorchis viverrini genome provides insights into life in the bile duct

Neil D. Young, Niranjan Nagarajan, Suling Joyce Lin, Pasi K. Korhonen, Aaron R. Jex, Ross S. Hall, Helena Safavi-Hemami, Worasak Kaewkong, Denis Bertrand, Song Gao, Qihui Seet, Sopit Wongkham, Bin Tean Teh, Chaisiri Wongkham, Pewpan Maleewong Intapan, Wanchai Maleewong, Xinhua Yang, Min Hu, Zuo Wang, Andreas Hofmann & 4 others Paul W. Sternberg, Patrick Tan, Jun Wang, Robin B. Gasser

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel) is used against the parasite. Little is known about O. viverrini biology and the diseases that it causes. Here we characterize the draft genome (634.5Mb) and transcriptomes of O. viverrini, elucidate how this fluke survives in the hostile environment within the bile duct and show that metabolic pathways in the parasite are highly adapted to a lipid-rich diet from bile and/or cholangiocytes. We also provide additional evidence that O. viverrini and other flukes secrete proteins that directly modulate host cell proliferation. Our molecular resources now underpin profound explorations of opisthorchiasis/CCA and the design of new interventions.

LanguageEnglish
Article number4378
JournalNature communications
Volume5
DOIs
Publication statusPublished - 9 Jul 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Young, N. D., Nagarajan, N., Lin, S. J., Korhonen, P. K., Jex, A. R., Hall, R. S., ... Gasser, R. B. (2014). The Opisthorchis viverrini genome provides insights into life in the bile duct. Nature communications, 5, [4378]. https://doi.org/10.1038/ncomms5378
Young, Neil D. ; Nagarajan, Niranjan ; Lin, Suling Joyce ; Korhonen, Pasi K. ; Jex, Aaron R. ; Hall, Ross S. ; Safavi-Hemami, Helena ; Kaewkong, Worasak ; Bertrand, Denis ; Gao, Song ; Seet, Qihui ; Wongkham, Sopit ; Teh, Bin Tean ; Wongkham, Chaisiri ; Intapan, Pewpan Maleewong ; Maleewong, Wanchai ; Yang, Xinhua ; Hu, Min ; Wang, Zuo ; Hofmann, Andreas ; Sternberg, Paul W. ; Tan, Patrick ; Wang, Jun ; Gasser, Robin B. / The Opisthorchis viverrini genome provides insights into life in the bile duct. In: Nature communications. 2014 ; Vol. 5.
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abstract = "Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel) is used against the parasite. Little is known about O. viverrini biology and the diseases that it causes. Here we characterize the draft genome (634.5Mb) and transcriptomes of O. viverrini, elucidate how this fluke survives in the hostile environment within the bile duct and show that metabolic pathways in the parasite are highly adapted to a lipid-rich diet from bile and/or cholangiocytes. We also provide additional evidence that O. viverrini and other flukes secrete proteins that directly modulate host cell proliferation. Our molecular resources now underpin profound explorations of opisthorchiasis/CCA and the design of new interventions.",
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Young, ND, Nagarajan, N, Lin, SJ, Korhonen, PK, Jex, AR, Hall, RS, Safavi-Hemami, H, Kaewkong, W, Bertrand, D, Gao, S, Seet, Q, Wongkham, S, Teh, BT, Wongkham, C, Intapan, PM, Maleewong, W, Yang, X, Hu, M, Wang, Z, Hofmann, A, Sternberg, PW, Tan, P, Wang, J & Gasser, RB 2014, 'The Opisthorchis viverrini genome provides insights into life in the bile duct', Nature communications, vol. 5, 4378. https://doi.org/10.1038/ncomms5378

The Opisthorchis viverrini genome provides insights into life in the bile duct. / Young, Neil D.; Nagarajan, Niranjan; Lin, Suling Joyce; Korhonen, Pasi K.; Jex, Aaron R.; Hall, Ross S.; Safavi-Hemami, Helena; Kaewkong, Worasak; Bertrand, Denis; Gao, Song; Seet, Qihui; Wongkham, Sopit; Teh, Bin Tean; Wongkham, Chaisiri; Intapan, Pewpan Maleewong; Maleewong, Wanchai; Yang, Xinhua; Hu, Min; Wang, Zuo; Hofmann, Andreas; Sternberg, Paul W.; Tan, Patrick; Wang, Jun; Gasser, Robin B.

In: Nature communications, Vol. 5, 4378, 09.07.2014.

Research output: Contribution to journalArticle

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AU - Young, Neil D.

AU - Nagarajan, Niranjan

AU - Lin, Suling Joyce

AU - Korhonen, Pasi K.

AU - Jex, Aaron R.

AU - Hall, Ross S.

AU - Safavi-Hemami, Helena

AU - Kaewkong, Worasak

AU - Bertrand, Denis

AU - Gao, Song

AU - Seet, Qihui

AU - Wongkham, Sopit

AU - Teh, Bin Tean

AU - Wongkham, Chaisiri

AU - Intapan, Pewpan Maleewong

AU - Maleewong, Wanchai

AU - Yang, Xinhua

AU - Hu, Min

AU - Wang, Zuo

AU - Hofmann, Andreas

AU - Sternberg, Paul W.

AU - Tan, Patrick

AU - Wang, Jun

AU - Gasser, Robin B.

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Young ND, Nagarajan N, Lin SJ, Korhonen PK, Jex AR, Hall RS et al. The Opisthorchis viverrini genome provides insights into life in the bile duct. Nature communications. 2014 Jul 9;5. 4378. https://doi.org/10.1038/ncomms5378