The mTOR pathway in the control of protein synthesis

Research output: Contribution to journalReview article

404 Citations (Scopus)

Abstract

Signaling through mammalian target of rapamycin (mTOR) is activated by amino acids, insulin, and growth factors, and impaired by nutrient or energy deficiency. mTOR plays key roles in cell physiology. mTOR regulates numerous components involved in protein synthesis, including initiation and elongation factors, and the biogenesis of ribosomes themselves.

Original languageEnglish
Pages (from-to)362-369
Number of pages8
JournalPhysiology
Volume21
Issue number5
DOIs
Publication statusPublished - 1 Oct 2006

ASJC Scopus subject areas

  • Physiology

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