The metabolism and anti-atherogenic properties of HDL

Kerry Anne Rye, Christina A. Bursill, Gilles Lambert, Fatiha Tabet, Philip J. Barter

Research output: Contribution to journalReview articlepeer-review

200 Citations (Scopus)

Abstract

Population studies have shown that plasma HDL levels correlate inversely with cardiovascular disease risk. In recent years there has been intense interest in developing strategies for exploiting these cardioprotective properties by increasing HDL levels. While this approach has considerable merit, it is important to recognize that HDL are structurally and functionally diverse and consist of numerous, highly dynamic subpopulations of particles that do not all inhibit atherosclerosis to the same extent. For this reason it is essential to assess HDL subpopulation distribution and functionality when considering therapeutic interventions that raise HDL levels. This review documents what is known about the relationship between the metabolism and function of HDL subpopulations and how this affects their cardioprotective properties.

Original languageEnglish
Pages (from-to)S195-S200
JournalJournal of Lipid Research
Volume50
Issue numberSUPPL.
DOIs
Publication statusPublished - Apr 2009
Externally publishedYes

Keywords

  • HDL function
  • HDL remodelling
  • HDL subpopulations

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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