The metabolic syndrome

Robert H. Eckel, Scott M. Grundy, Paul Zimmet

Research output: Contribution to journalArticle

4044 Citations (Scopus)

Abstract

The metabolic syndrome is a common metabolic disorder that results from the increasing prevalence of obesity. The disorder is defined in various ways, but in the near future a new definition(s) will be applicable worldwide. The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated. A proinflammatory state probably contributes to the syndrome. The increased risk for type 2 diabetes and cardiovascular disease demands therapeutic attention for those at high risk. The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction.

LanguageEnglish
Pages1415-1428
Number of pages14
JournalLancet
Volume365
Issue number9468
DOIs
Publication statusPublished - 16 Apr 2005

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Eckel, R. H., Grundy, S. M., & Zimmet, P. (2005). The metabolic syndrome. Lancet, 365(9468), 1415-1428. https://doi.org/10.1016/S0140-6736(05)66378-7