The international HapMap project

John W. Belmont, Paul Hardenbol, Thomas D. Willis, Fuli Yu, Huanming Yang, Lan Yang Ch'Ang, Wei Huang, Bin Liu, Yan Shen, Paul Kwong Hang Tam, Lap Chee Tsui, Mary Miu Yee Waye, Jeffrey Tze Fei Wong, Changqing Zeng, Qingrun Zhang, Mark S. Chee, Luana M. Galver, Semyon Kruglyak, Sarah S. Murray, Arnold R. Oliphant & 124 others Alexandre Montpetit, Fanny Chagnon, Vincent Ferretti, Martin Leboeuf, Michael S. Phillips, Andrei Verner, Shenghui Duan, Denise L. Lind, Raymond D. Miller, John Rice, Nancy L. Saccone, Patricia Taillon-Miller, Ming Xiao, Akihiro Sekine, Koki Sorimachi, Yoichi Tanaka, Tatsuhiko Tsunoda, Eiji Yoshino, David R. Bentley, Sarah Hunt, Don Powell, Houcan Zhang, Ichiro Matsuda, Yoshimitsu Fukushima, Darryl R. Macer, Eiko Suda, Charles Rotimi, Clement A. Adebamowo, Toyin Aniagwu, Patricia A. Marshall, Olayemi Matthew, Chibuzor Nkwodimmah, Charmaine D.M. Royal, Mark F. Leppert, Missy Dixon, Fiona Cunningham, Ardavan Kanani, Gudmundur A. Thorisson, Peter E. Chen, David J. Cutler, Carl S. Kashuk, Peter Donnelly, Jonathan Marchini, Gilean A.T. McVean, Simon R. Myers, Lon R. Cardon, Andrew Morris, Bruce S. Weir, James C. Mullikin, Michael Feolo, Mark J. Daly, Renzong Qiu, Alastair Kent, Georgia M. Dunston, Kazuto Kato, Norio Niikawa, Jessica Watkin, Richard A. Gibbs, Erica Sodergren, George M. Weinstock, Richard K. Wilson, Lucinda L. Fulton, Jane Rogers, Bruce W. Birren, Hua Han, Hongguang Wang, Martin Godbout, John C. Wallenburg, Paul L'Archevêque, Guy Bellemare, Kazuo Todani, Takashi Fujita, Satoshi Tanaka, Arthur L. Holden, Francis S. Collins, Lisa D. Brooks, Jean E. McEwen, Mark S. Guyer, Elke Jordan, Jane L. Peterson, Jack Spiegel, Lawrence M. Sung, Lynn F. Zacharia, Karen Kennedy, Michael G. Dunn, Richard Seabrook, Mark Shillito, Barbara Skene, John G. Stewart, David L. Valle, Ellen Wright Clayton, Lynn B. Jorde, Aravinda Chakravarti, Mildred K. Cho, Troy Duster, Morris W. Foster, Maria Jasperse, Bartha M. Knoppers, Pui Yan Kwok, Julio Licinio, Jeffrey C. Long, Pilar Ossorio, Vivian Ota Wang, Charles N. Rotimi, Patricia Spallone, Sharon F. Terry, Eric S. Lander, Eric H. Lai, Deborah A. Nickerson, Gonçalo R. Abecasis, David Altshuler, Michael Boehnke, Panos Deloukas, Julie A. Douglas, Stacey B. Gabriel, Richard R. Hudson, Thomas J. Hudson, Leonid Kruglyak, Yusuke Nakamura, Robert L. Nussbaum, Stephen F. Schaffner, Stephen T. Sherry, Lincoln D. Stein, Toshihiro Tanaka

Research output: Contribution to journalArticle

4470 Citations (Scopus)

Abstract

The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance our ability to choose targets for therapeutic intervention.

LanguageEnglish
Pages789-796
Number of pages8
JournalNature
Volume426
Issue number6968
DOIs
Publication statusPublished - 18 Dec 2003

ASJC Scopus subject areas

  • General

Cite this

Belmont, J. W., Hardenbol, P., Willis, T. D., Yu, F., Yang, H., Ch'Ang, L. Y., ... Tanaka, T. (2003). The international HapMap project. Nature, 426(6968), 789-796. https://doi.org/10.1038/nature02168