The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation: A meta-analysis

M. M E Van Rumste, I. M. Custers, F. Van Der Veen, M. Van Wely, J. L H Evers, B. W J Mol

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Background: The influence of multifollicular growth on pregnancy rates in subfertile couples undergoing intrauterine insemination (IUI) with controlled ovarian hyperstimulation (COH) remained unclear. Methods: Relevant papers were identified by searching MEDLINE, EMBASE and the Cochrane Library. A meta-analysis was performed and Mantel-Haenszel pooled odd ratios (ORs) and risk differences with 99% confidence intervals (CIs) were calculated to express the relation between the number of follicles and pregnancy rates. Results: We included 14 studies reporting on 11 599 cycles. The absolute pregnancy rate was 8.4% for monofollicular and 15% for multifollicular growth. The pooled OR for pregnancy after two follicles as compared with monofollicular growth was 1.6 (99% CI 1.3-2.0), whereas for three and four follicles, this was 2.0 and 2.0, respectively. Compared with monofollicular growth, pregnancy rates increased by 5, 8 and 8% when stimulating two, three and four follicles. The pooled OR for multiple pregnancies after two follicles was 1.7 (99% CI 0.8-3.6), whereas for three and four follicles this was 2.8 and 2.3, respectively. The risk of multiple pregnancies after two, three and four follicles increased by 6, 14 and 10%. The absolute rate of multiple pregnancies was 0.3% after monofollicular and 2.8% after multifollicular growth. Conclusions: Multifollicular growth is associated with increased pregnancy rates in IUI with COH. Since in cycles with three or four follicles the multiple pregnancy rate increased without substantial gain in overall pregnancy rate, IUI with COH should not aim for more than two follicles. One stimulated follicle should be the goal if safety is the primary concern, whereas two follicles may be accepted after careful patient counselling.

LanguageEnglish
Pages563-570
Number of pages8
JournalHuman Reproduction Update
Volume14
Issue number6
DOIs
Publication statusPublished - 29 Oct 2008

Keywords

  • Follicle number
  • Intrauterine insemination
  • Ovarian stimulation
  • Pregnancy rate
  • Systematic review

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Van Rumste, M. M. E., Custers, I. M., Van Der Veen, F., Van Wely, M., Evers, J. L. H., & Mol, B. W. J. (2008). The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation: A meta-analysis. Human Reproduction Update, 14(6), 563-570. https://doi.org/10.1093/humupd/dmn034
Van Rumste, M. M E ; Custers, I. M. ; Van Der Veen, F. ; Van Wely, M. ; Evers, J. L H ; Mol, B. W J. / The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation : A meta-analysis. In: Human Reproduction Update. 2008 ; Vol. 14, No. 6. pp. 563-570.
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abstract = "Background: The influence of multifollicular growth on pregnancy rates in subfertile couples undergoing intrauterine insemination (IUI) with controlled ovarian hyperstimulation (COH) remained unclear. Methods: Relevant papers were identified by searching MEDLINE, EMBASE and the Cochrane Library. A meta-analysis was performed and Mantel-Haenszel pooled odd ratios (ORs) and risk differences with 99{\%} confidence intervals (CIs) were calculated to express the relation between the number of follicles and pregnancy rates. Results: We included 14 studies reporting on 11 599 cycles. The absolute pregnancy rate was 8.4{\%} for monofollicular and 15{\%} for multifollicular growth. The pooled OR for pregnancy after two follicles as compared with monofollicular growth was 1.6 (99{\%} CI 1.3-2.0), whereas for three and four follicles, this was 2.0 and 2.0, respectively. Compared with monofollicular growth, pregnancy rates increased by 5, 8 and 8{\%} when stimulating two, three and four follicles. The pooled OR for multiple pregnancies after two follicles was 1.7 (99{\%} CI 0.8-3.6), whereas for three and four follicles this was 2.8 and 2.3, respectively. The risk of multiple pregnancies after two, three and four follicles increased by 6, 14 and 10{\%}. The absolute rate of multiple pregnancies was 0.3{\%} after monofollicular and 2.8{\%} after multifollicular growth. Conclusions: Multifollicular growth is associated with increased pregnancy rates in IUI with COH. Since in cycles with three or four follicles the multiple pregnancy rate increased without substantial gain in overall pregnancy rate, IUI with COH should not aim for more than two follicles. One stimulated follicle should be the goal if safety is the primary concern, whereas two follicles may be accepted after careful patient counselling.",
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The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation : A meta-analysis. / Van Rumste, M. M E; Custers, I. M.; Van Der Veen, F.; Van Wely, M.; Evers, J. L H; Mol, B. W J.

In: Human Reproduction Update, Vol. 14, No. 6, 29.10.2008, p. 563-570.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation

T2 - Human Reproduction Update

AU - Van Rumste, M. M E

AU - Custers, I. M.

AU - Van Der Veen, F.

AU - Van Wely, M.

AU - Evers, J. L H

AU - Mol, B. W J

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N2 - Background: The influence of multifollicular growth on pregnancy rates in subfertile couples undergoing intrauterine insemination (IUI) with controlled ovarian hyperstimulation (COH) remained unclear. Methods: Relevant papers were identified by searching MEDLINE, EMBASE and the Cochrane Library. A meta-analysis was performed and Mantel-Haenszel pooled odd ratios (ORs) and risk differences with 99% confidence intervals (CIs) were calculated to express the relation between the number of follicles and pregnancy rates. Results: We included 14 studies reporting on 11 599 cycles. The absolute pregnancy rate was 8.4% for monofollicular and 15% for multifollicular growth. The pooled OR for pregnancy after two follicles as compared with monofollicular growth was 1.6 (99% CI 1.3-2.0), whereas for three and four follicles, this was 2.0 and 2.0, respectively. Compared with monofollicular growth, pregnancy rates increased by 5, 8 and 8% when stimulating two, three and four follicles. The pooled OR for multiple pregnancies after two follicles was 1.7 (99% CI 0.8-3.6), whereas for three and four follicles this was 2.8 and 2.3, respectively. The risk of multiple pregnancies after two, three and four follicles increased by 6, 14 and 10%. The absolute rate of multiple pregnancies was 0.3% after monofollicular and 2.8% after multifollicular growth. Conclusions: Multifollicular growth is associated with increased pregnancy rates in IUI with COH. Since in cycles with three or four follicles the multiple pregnancy rate increased without substantial gain in overall pregnancy rate, IUI with COH should not aim for more than two follicles. One stimulated follicle should be the goal if safety is the primary concern, whereas two follicles may be accepted after careful patient counselling.

AB - Background: The influence of multifollicular growth on pregnancy rates in subfertile couples undergoing intrauterine insemination (IUI) with controlled ovarian hyperstimulation (COH) remained unclear. Methods: Relevant papers were identified by searching MEDLINE, EMBASE and the Cochrane Library. A meta-analysis was performed and Mantel-Haenszel pooled odd ratios (ORs) and risk differences with 99% confidence intervals (CIs) were calculated to express the relation between the number of follicles and pregnancy rates. Results: We included 14 studies reporting on 11 599 cycles. The absolute pregnancy rate was 8.4% for monofollicular and 15% for multifollicular growth. The pooled OR for pregnancy after two follicles as compared with monofollicular growth was 1.6 (99% CI 1.3-2.0), whereas for three and four follicles, this was 2.0 and 2.0, respectively. Compared with monofollicular growth, pregnancy rates increased by 5, 8 and 8% when stimulating two, three and four follicles. The pooled OR for multiple pregnancies after two follicles was 1.7 (99% CI 0.8-3.6), whereas for three and four follicles this was 2.8 and 2.3, respectively. The risk of multiple pregnancies after two, three and four follicles increased by 6, 14 and 10%. The absolute rate of multiple pregnancies was 0.3% after monofollicular and 2.8% after multifollicular growth. Conclusions: Multifollicular growth is associated with increased pregnancy rates in IUI with COH. Since in cycles with three or four follicles the multiple pregnancy rate increased without substantial gain in overall pregnancy rate, IUI with COH should not aim for more than two follicles. One stimulated follicle should be the goal if safety is the primary concern, whereas two follicles may be accepted after careful patient counselling.

KW - Follicle number

KW - Intrauterine insemination

KW - Ovarian stimulation

KW - Pregnancy rate

KW - Systematic review

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DO - 10.1093/humupd/dmn034

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