The Implications of Obesity for Cardiac Arrhythmia Mechanisms and Management

Rajeev K. Pathak, Rajiv Mahajan, Dennis H. Lau, Prashanthan Sanders

Research output: Contribution to journalReview article

35 Citations (Scopus)


The ever-increasing prevalence of obesity poses a significant burden on the health care system with escalating socioeconomic consequences. At the individual level, obesity is well recognized to increase morbidity and mortality. Not only is obesity an established cardiovascular risk factor, it also increases the risk of sudden cardiac death and atrial fibrillation. Studies have shown that increased adiposity itself and the accompanying metabolic consequences of weight gain contribute to an abnormal arrhythmogenic substrate. In this review, we focus on the diverse mechanisms underlying cardiac arrhythmias related to obesity. In particular, we highlight the pathogenic role of adipose depots leading to increased atrial fibrillation and the effect of weight reduction in decreasing atrial fibrillation burden in obese individuals.

Original languageEnglish
Pages (from-to)203-210
Number of pages8
JournalCanadian Journal of Cardiology
Issue number2
Publication statusPublished - 1 Jan 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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