The hypothalamic-pituitary-adrenal axis in anorexia nervosa

Júlio Licinio, Ma Li Wong, Philip W. Gold

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Studies examining the function of the hypothalamic-pituitary-adrenal (HPA) axis in anorexia nervosa are reviewed. A principal finding is that of hypercortisolism, associated with increased central corticotropin-releasing hormone levels and normal circulating levels of adrenocorticotropic hormone. Similarities between neuroendocrine findings in anorexia nervosa and in affective disorder are reviewed. The contribution of circadian rhythm disturbances and malnutrition to observed HPA axis abnormalities in anorexia nervosa is also considered. Directions for future research are discussed.

LanguageEnglish
Pages75-83
Number of pages9
JournalPsychiatry Research
Volume62
Issue number1
DOIs
Publication statusPublished - 16 Apr 1996

Keywords

  • Adrenocorticotropic hormone
  • Circadian rhythms
  • Corticotropin-releasing hormone
  • Cortisol
  • Depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Licinio, Júlio ; Wong, Ma Li ; Gold, Philip W. / The hypothalamic-pituitary-adrenal axis in anorexia nervosa. In: Psychiatry Research. 1996 ; Vol. 62, No. 1. pp. 75-83.
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The hypothalamic-pituitary-adrenal axis in anorexia nervosa. / Licinio, Júlio; Wong, Ma Li; Gold, Philip W.

In: Psychiatry Research, Vol. 62, No. 1, 16.04.1996, p. 75-83.

Research output: Contribution to journalArticle

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