The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific

Andrey N. Shkoporov, Adam G. Clooney, Thomas D.S. Sutton, Feargal Ryan, Karen M. Daly, James A. Nolan, Siobhan A. McDonnell, Ekaterina V. Khokhlova, Lorraine A. Draper, Amanda Forde, Emma Guerin, Vimalkumar Velayudhan, R. Paul Ross, Colin Hill

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Shkoporov et al. demonstrate high individual specificity and temporal stability of the human gut virome. They describe a numerically prevalent and persisting fraction of the viral community, termed persistent personal virome (PPV). The PPV consists mainly of virulent bacteriophages predicted to target major taxonomic groups of gut bacteria.

LanguageEnglish
Pages527-541.e5
JournalCell Host and Microbe
Volume26
Issue number4
DOIs
Publication statusPublished - 9 Oct 2019

Keywords

  • CRISPR
  • Microviridae
  • bacteriophages
  • crAss-like phages
  • crAssphage
  • human microbiome
  • longitudinal study
  • persistent personal virome
  • phageome
  • virome

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

Cite this

Shkoporov, A. N., Clooney, A. G., Sutton, T. D. S., Ryan, F., Daly, K. M., Nolan, J. A., ... Hill, C. (2019). The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific. Cell Host and Microbe, 26(4), 527-541.e5. https://doi.org/10.1016/j.chom.2019.09.009