The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes

T. N. Dear, I. Sanchez-Garcia, T. H. Rabbitts

Research output: Contribution to journalArticlepeer-review

113 Citations (Scopus)

Abstract

A translocation involving human chromosome 10, band q24, in a subset of T- cell acute leukemias disrupts a region surrounding the putative oncogene HOX11, which encodes a protein with a homeodomain. The HOX11 protein binds to a specific DNA sequence, it localizes to the cell nucleus, and it transactivates transcription of a reporter gene linked to a cis-regulatory element, suggesting that HOX11 functions in vivo as a positive transcription activator. PCR analysis shows that the HOX11 homeodomain is a member of a distinct class of homeodomains, representatives of which occur in murine and Drosophila genomes. These all contain a threonine residue in place of the more common isoleucine or valine in helix 3 of the homeodomain. HOX11 therefore appears to belong to a family of DNA-binding transactivators of transcription.

Original languageEnglish
Pages (from-to)4431-4435
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number10
DOIs
Publication statusPublished - 1 Jan 1993

Keywords

  • T-cell leukemia
  • chromosome translocation
  • homeodomain

ASJC Scopus subject areas

  • General

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