The histological and ultrastructural features of the epiphyseal plate in morquio type a syndrome (mucopolysaccharidosis type IVA)

John McClure, P. S. Smith, G. Sorby-Adamsi, J. Hopwood

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19 Citations (Scopus)

Abstract

Tissue from the epiphyseal plate of a patient with Morquio type A syndrome (mucopolysaccharidosis type IVA) was studied by undecalcified histological and electron microscopical techniques. Cartilage cells in the plate were vacuolated to a variable degree. The orderly proliferating structure of the epiphyseal plate was absent and calcification was markedly reduced. The related bone tissue was morphologically normal although reduced in quantity.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalPathology
Volume18
Issue number2
DOIs
Publication statusPublished - 1 Jan 1986
Externally publishedYes

Keywords

  • Chondrocyte vacuolation
  • Morquio type A syndrome
  • Reduced calcification

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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