The extracellular matrix in digestive cancer

Daniel L. Worthley, Andrew S. Giraud, Timothy C. Wang

Research output: Contribution to journalArticle

9 Citations (Scopus)


The extracellular components of the cancer microenvironment play a critical role in tumor initiation, progression and invasion. In this review we examine the normal formation and function of the basement membrane and extracellular matrix. We characterize the interactions between the matrix and the epithelium and explore the causes and consequences of the extracellular remodeling that accompanies carcinogenesis. Finally, we address the therapeutic possibilities of incorporating matrix as well as epithelial strategies in the management of digestive cancer.

Original languageEnglish
Pages (from-to)177-185
Number of pages9
JournalCancer Microenvironment
Issue number1
Publication statusPublished - 1 Dec 2010


  • Bone-marrow derived cells
  • Cancer
  • Cancer stroma
  • Digestive system neoplasms
  • Extracellular matrix
  • Gastrointestinal cancer
  • Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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