The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma

S. K. Martin, P. Diamond, S. Gronthos, D. J. Peet, A. C W Zannettino

Research output: Contribution to journalReview article

77 Citations (Scopus)

Abstract

Hypoxia is an imbalance between oxygen supply and demand, which deprives cells or tissues of sufficient oxygen. It is well-established that hypoxia triggers adaptive responses, which contribute to short-and long-term pathologies such as inflammation, cardiovascular disease and cancer. Induced by both microenvironmental hypoxia and genetic mutations, the elevated expression of the hypoxia-inducible transcription factor-1 (HIF-1) and HIF-2 is a key feature of many human cancers and has been shown to promote cellular processes, which facilitate tumor progression. In this review, we discuss the emerging role of hypoxia and the HIFs in the pathogenesis of multiple myeloma (MM), an incurable hematological malignancy of BM PCs, which reside within the hypoxic BM microenvironment. The need for current and future therapeutic interventions to target HIF-1 and HIF-2 in myeloma will also be discussed.

LanguageEnglish
Pages1533-1542
Number of pages10
JournalLeukemia
Volume25
Issue number10
DOIs
Publication statusPublished - 1 Jan 2011

Keywords

  • HIF-1
  • HIF-2
  • hypoxia
  • multiple myeloma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

@article{b955c94024b04a9aba2926b921183d61,
title = "The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma",
abstract = "Hypoxia is an imbalance between oxygen supply and demand, which deprives cells or tissues of sufficient oxygen. It is well-established that hypoxia triggers adaptive responses, which contribute to short-and long-term pathologies such as inflammation, cardiovascular disease and cancer. Induced by both microenvironmental hypoxia and genetic mutations, the elevated expression of the hypoxia-inducible transcription factor-1 (HIF-1) and HIF-2 is a key feature of many human cancers and has been shown to promote cellular processes, which facilitate tumor progression. In this review, we discuss the emerging role of hypoxia and the HIFs in the pathogenesis of multiple myeloma (MM), an incurable hematological malignancy of BM PCs, which reside within the hypoxic BM microenvironment. The need for current and future therapeutic interventions to target HIF-1 and HIF-2 in myeloma will also be discussed.",
keywords = "HIF-1, HIF-2, hypoxia, multiple myeloma",
author = "Martin, {S. K.} and P. Diamond and S. Gronthos and Peet, {D. J.} and Zannettino, {A. C W}",
year = "2011",
month = "1",
day = "1",
doi = "10.1038/leu.2011.122",
language = "English",
volume = "25",
pages = "1533--1542",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "10",

}

The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma. / Martin, S. K.; Diamond, P.; Gronthos, S.; Peet, D. J.; Zannettino, A. C W.

In: Leukemia, Vol. 25, No. 10, 01.01.2011, p. 1533-1542.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma

AU - Martin, S. K.

AU - Diamond, P.

AU - Gronthos, S.

AU - Peet, D. J.

AU - Zannettino, A. C W

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Hypoxia is an imbalance between oxygen supply and demand, which deprives cells or tissues of sufficient oxygen. It is well-established that hypoxia triggers adaptive responses, which contribute to short-and long-term pathologies such as inflammation, cardiovascular disease and cancer. Induced by both microenvironmental hypoxia and genetic mutations, the elevated expression of the hypoxia-inducible transcription factor-1 (HIF-1) and HIF-2 is a key feature of many human cancers and has been shown to promote cellular processes, which facilitate tumor progression. In this review, we discuss the emerging role of hypoxia and the HIFs in the pathogenesis of multiple myeloma (MM), an incurable hematological malignancy of BM PCs, which reside within the hypoxic BM microenvironment. The need for current and future therapeutic interventions to target HIF-1 and HIF-2 in myeloma will also be discussed.

AB - Hypoxia is an imbalance between oxygen supply and demand, which deprives cells or tissues of sufficient oxygen. It is well-established that hypoxia triggers adaptive responses, which contribute to short-and long-term pathologies such as inflammation, cardiovascular disease and cancer. Induced by both microenvironmental hypoxia and genetic mutations, the elevated expression of the hypoxia-inducible transcription factor-1 (HIF-1) and HIF-2 is a key feature of many human cancers and has been shown to promote cellular processes, which facilitate tumor progression. In this review, we discuss the emerging role of hypoxia and the HIFs in the pathogenesis of multiple myeloma (MM), an incurable hematological malignancy of BM PCs, which reside within the hypoxic BM microenvironment. The need for current and future therapeutic interventions to target HIF-1 and HIF-2 in myeloma will also be discussed.

KW - HIF-1

KW - HIF-2

KW - hypoxia

KW - multiple myeloma

UR - http://www.scopus.com/inward/record.url?scp=80054022144&partnerID=8YFLogxK

U2 - 10.1038/leu.2011.122

DO - 10.1038/leu.2011.122

M3 - Review article

VL - 25

SP - 1533

EP - 1542

JO - Leukemia

T2 - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 10

ER -