The effects of stress on brain and adrenal stem cells

M. F R De Celis, S. R. Bornstein, A. Androutsellis-Theotokis, C. L. Andoniadou, J. Licinio, M. L. Wong, M. Ehrhart-Bornstein

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The brain and adrenal are critical control centers that maintain body homeostasis under basal and stress conditions, and orchestrate the body's response to stress. It is noteworthy that patients with stress-related disorders exhibit increased vulnerability to mental illness, even years after the stress experience, which is able to generate long-term changes in the brain's architecture and function. High levels of glucocorticoids produced by the adrenal cortex of the stressed subject reduce neurogenesis, which contributes to the development of depression. In support of the brain-adrenal connection in stress, many (but not all) depressed patients have alterations in the components of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis, with enlarged adrenal cortex and increased glucocorticoid levels. Other psychiatric disorders, such as post-traumatic stress disorder, bipolar disorder and depression, are also associated with abnormalities in hippocampal volume and hippocampal function. In addition, hippocampal lesions impair the regulation of the LHPA axis in stress response. Our knowledge of the functional connection between stress, brain function and adrenal has been further expanded by two recent, independent papers that elucidate the effects of stress on brain and adrenal stem cells, showing similarities in the way that the progenitor populations of these organs behave under stress, and shedding more light into the potential cellular and molecular mechanisms involved in the adaptation of tissues to stress.

Original languageEnglish
Pages (from-to)590-593
Number of pages4
JournalMolecular Psychiatry
Volume21
Issue number5
DOIs
Publication statusPublished - 1 May 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

De Celis, M. F. R., Bornstein, S. R., Androutsellis-Theotokis, A., Andoniadou, C. L., Licinio, J., Wong, M. L., & Ehrhart-Bornstein, M. (2016). The effects of stress on brain and adrenal stem cells. Molecular Psychiatry, 21(5), 590-593. https://doi.org/10.1038/mp.2015.230