The effect of suramin on vasodilator responses to ATP and 2-methylthio-ATP in the Sprague-Dawley rat coronary vasculature

Amanda J. Vials, Geoffrey Burnstock

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effect of suramin, a P2 purinoceptor antagonist, on the vasodilator response to adenosine 5′-triphosphate (ATP), 2-methylthio-ATP (2-meSATP) and adenosine were examined in the Sprague-Dawley rat coronary vasculature using the Langendorff heart preparation. Relaxation induced by 2-meSATP was significantly inhibited by suramin. Only responses to low doses of adenosine and ATP were inhibited bu suramin. 8-(p-Sulphophenyl)theophylline (8-PSPT) did not affect the relaxant response to ATP and 2-meSATP at a concentration that significantly inhibited the response to adenosine. It is concluded that 2-meSATP acts via P2Y purinoceptors while ATP appears to be acting largely through a different mechanism. It is not acting via a P1 purinoceptor because ATP was not inhibited by the P1 purinoceptor antagonist 8-PSPT.

Original languageEnglish
Pages (from-to)299-302
Number of pages4
JournalEuropean Journal of Pharmacology
Volume251
Issue number2-3
DOIs
Publication statusPublished - 14 Jan 1994

Keywords

  • Coronary vasculature
  • P purinoceptor
  • Suramin

ASJC Scopus subject areas

  • Pharmacology

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