The effect of n-3 LCPUFA supplementation on oxidative stress and inflammation in the placenta and maternal plasma during pregnancy

G. E. Leghi, B. S. Muhlhausler

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)

Abstract

Pregnancy represents a state of heightened oxidative stress and inflammation, and these processes are further increased in pregnancy complications. The quality of the maternal diet is directly associated with maternal health and wellbeing, pregnancy and fetal outcomes, as well as the risk of pregnancy complications. Long chain polyunsaturated fatty acids (LCPUFAs) have significant potential to modify placental and fetal lipid environments and thereby modulate health outcomes. The omega-3 (n-3) LCPUFA in particular have been shown to exhibit both antioxidant and anti-inflammatory properties, and have potential therapeutic applications in reducing oxidative damage and inflammation during pregnancy. The purpose of this review is to provide an overview of our current understanding of the impact of maternal n-3 LCPUFA supplementation on oxidative stress and inflammation during pregnancy, with a particular focus on effects on the mother and the placenta.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume113
DOIs
Publication statusPublished or Issued - 1 Oct 2016

Keywords

  • Inflammation
  • Nutrition
  • Omega-3 fatty acids
  • Oxidative stress
  • Placenta
  • Pregnancy

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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