The effect of n-3 LCPUFA supplementation on oxidative stress and inflammation in the placenta and maternal plasma during pregnancy

G. E. Leghi, B. S. Muhlhausler

    Research output: Contribution to journalReview article

    12 Citations (Scopus)

    Abstract

    Pregnancy represents a state of heightened oxidative stress and inflammation, and these processes are further increased in pregnancy complications. The quality of the maternal diet is directly associated with maternal health and wellbeing, pregnancy and fetal outcomes, as well as the risk of pregnancy complications. Long chain polyunsaturated fatty acids (LCPUFAs) have significant potential to modify placental and fetal lipid environments and thereby modulate health outcomes. The omega-3 (n-3) LCPUFA in particular have been shown to exhibit both antioxidant and anti-inflammatory properties, and have potential therapeutic applications in reducing oxidative damage and inflammation during pregnancy. The purpose of this review is to provide an overview of our current understanding of the impact of maternal n-3 LCPUFA supplementation on oxidative stress and inflammation during pregnancy, with a particular focus on effects on the mother and the placenta.

    LanguageEnglish
    Pages33-39
    Number of pages7
    JournalProstaglandins Leukotrienes and Essential Fatty Acids
    Volume113
    DOIs
    Publication statusPublished - 1 Oct 2016

    Keywords

    • Inflammation
    • Nutrition
    • Omega-3 fatty acids
    • Oxidative stress
    • Placenta
    • Pregnancy

    ASJC Scopus subject areas

    • Clinical Biochemistry
    • Cell Biology

    Cite this

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    abstract = "Pregnancy represents a state of heightened oxidative stress and inflammation, and these processes are further increased in pregnancy complications. The quality of the maternal diet is directly associated with maternal health and wellbeing, pregnancy and fetal outcomes, as well as the risk of pregnancy complications. Long chain polyunsaturated fatty acids (LCPUFAs) have significant potential to modify placental and fetal lipid environments and thereby modulate health outcomes. The omega-3 (n-3) LCPUFA in particular have been shown to exhibit both antioxidant and anti-inflammatory properties, and have potential therapeutic applications in reducing oxidative damage and inflammation during pregnancy. The purpose of this review is to provide an overview of our current understanding of the impact of maternal n-3 LCPUFA supplementation on oxidative stress and inflammation during pregnancy, with a particular focus on effects on the mother and the placenta.",
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    The effect of n-3 LCPUFA supplementation on oxidative stress and inflammation in the placenta and maternal plasma during pregnancy. / Leghi, G. E.; Muhlhausler, B. S.

    In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 113, 01.10.2016, p. 33-39.

    Research output: Contribution to journalReview article

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    KW - Nutrition

    KW - Omega-3 fatty acids

    KW - Oxidative stress

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