The effect of modifying dietary LA and ALA intakes on omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in human adults: A systematic review and commentary

K. E. Wood, E. Mantzioris, R. A. Gibson, C. E. Ramsden, B. S. Muhlhausler

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


This paper presents a systematic review of human studies investigating the effect of altering dietary omega-3 polyunsaturated fatty acid (n-3 PUFA) alpha-linolenic acid (ALA) and omega-6 polyunsaturated fatty acid (n-6 PUFA) linoleic acid (LA) intakes on n-3 long-chain polyunsaturated fatty acid (LCPUFA) status in adult humans. The results suggest that it is possible to increase n-3 LCPUFA status by reducing LA and/or increasing ALA intake in humans, although decreasing LA intake to below 2.5%. E may be required to specifically increase levels of the n-3 LCPUFA docosahexaenoic acid (DHA). The majority of studies in this area to date have been relatively poor in quality, which limits the ability to draw robust conclusions, and we present a series of recommendations to improve the quality of future studies in fatty acid nutrition in humans.

Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Publication statusPublished or Issued - 1 Apr 2015


  • ALA
  • DHA
  • Diet
  • EPA
  • Human
  • LA

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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