TY - JOUR
T1 - The effect of frailty on outcomes of surgically treated hip fractures in older people
AU - Jorissen, Robert N.
AU - Lang, Catherine
AU - Visvanathan, Renuka
AU - Crotty, Maria
AU - Inacio, Maria C.
N1 - Funding Information:
This work was supported by funding provided by the National Health and Medical Research Council (NHMRC) Cognitive Decline Partnership Grant 9100000, and the South Australian Government through the Department for Innovation and Skills (2017?2021).The authors would like to acknowledge the Healthy Ageing Research Consortium Investigator Team and the Registry of Senior Australians (ROSA) Research Team at the South Australian Health and Medical Research Institute (SAHMRI) for their support with this study. We additionally acknowledge the South Australian Government who provide us with support (2017?2021) through the Department for Innovation and Skills, and the Australian Institute of Health and Welfare for the provision of the raw data that used in ROSA. We thank Dr. Gillian Caughey and Ms. Eliza Schioldann for critical comments on the manuscript. Ethics approval for this study was granted by the University of South Australia (ID 200489) and Australian Institute of Health and Welfare (EO2018/1/418) Human Research Ethics Committees.
Funding Information:
This work was supported by funding provided by the National Health and Medical Research Council (NHMRC) Cognitive Decline Partnership Grant 9100000 , and the South Australian Government through the Department for Innovation and Skills (2017–2021).
PY - 2020/7
Y1 - 2020/7
N2 - Background: Hip fractures are associated with mortality, disability, and loss of independence in older adults. While several risk factors associated with poor outcomes following a hip fracture have been identified, the effect of frailty status prior to hip fracture is not well established. Aim: To examine the associations of frailty with mortality, change in activities of daily living (ADL) limitations, and transition to permanent residential aged care in older people following a hip fracture. Methods: A retrospective cohort study was conducted on people aged 65 years and older with a surgically treated hip fracture between 2003 and 2015. Frailty was estimated using a cumulative deficit-based frailty index and categorized into quartiles. Cox multivariable regression, logistic regression, and Fine-Gray multivariable regression models estimated associations of frailty with mortality, ADL limitations, and entry into permanent residential aged care, respectively. Hazard ratios (HR), odds ratios (OR), subdistribution hazard ratios (SHR), and 95% confidence intervals (95%CI) are reported. Results: Out of 4771 individuals with hip fractures, 75.6% were female and the median age was 86 (interquartile range 82–90) years old. The two-year survival of patients following hip fracture was 43.7% (95%CI 40.9–46.7%) in those in the highest quartile of frailty, compared to 54.4% (95%CI 51.8–57.2%) for those in the lowest quartile (HR = 1.25, 95%CI 1.11–1.41, p < 0.001). No associations between pre-fracture frailty and post-fracture ADL limitations were observed. Additionally, no association of frailty with transition to permanent residential aged care for patients living in the community (n = 1361) was observed (SHR = 0.98, 95%CI 0.81–1.18, p = 1.000). Conclusions: Older patients with the highest level of frailty had an increased risk of mortality after hip fracture. Consideration for appropriate clinical interventions, including fall and frailty prevention measures, may be appropriate for this identified group of vulnerable individuals.
AB - Background: Hip fractures are associated with mortality, disability, and loss of independence in older adults. While several risk factors associated with poor outcomes following a hip fracture have been identified, the effect of frailty status prior to hip fracture is not well established. Aim: To examine the associations of frailty with mortality, change in activities of daily living (ADL) limitations, and transition to permanent residential aged care in older people following a hip fracture. Methods: A retrospective cohort study was conducted on people aged 65 years and older with a surgically treated hip fracture between 2003 and 2015. Frailty was estimated using a cumulative deficit-based frailty index and categorized into quartiles. Cox multivariable regression, logistic regression, and Fine-Gray multivariable regression models estimated associations of frailty with mortality, ADL limitations, and entry into permanent residential aged care, respectively. Hazard ratios (HR), odds ratios (OR), subdistribution hazard ratios (SHR), and 95% confidence intervals (95%CI) are reported. Results: Out of 4771 individuals with hip fractures, 75.6% were female and the median age was 86 (interquartile range 82–90) years old. The two-year survival of patients following hip fracture was 43.7% (95%CI 40.9–46.7%) in those in the highest quartile of frailty, compared to 54.4% (95%CI 51.8–57.2%) for those in the lowest quartile (HR = 1.25, 95%CI 1.11–1.41, p < 0.001). No associations between pre-fracture frailty and post-fracture ADL limitations were observed. Additionally, no association of frailty with transition to permanent residential aged care for patients living in the community (n = 1361) was observed (SHR = 0.98, 95%CI 0.81–1.18, p = 1.000). Conclusions: Older patients with the highest level of frailty had an increased risk of mortality after hip fracture. Consideration for appropriate clinical interventions, including fall and frailty prevention measures, may be appropriate for this identified group of vulnerable individuals.
KW - Aged care
KW - Frailty
KW - Hip fracture
KW - Older people
KW - Population-based retrospective cohort study
UR - http://www.scopus.com/inward/record.url?scp=85085118610&partnerID=8YFLogxK
U2 - 10.1016/j.bone.2020.115327
DO - 10.1016/j.bone.2020.115327
M3 - Article
C2 - 32209422
AN - SCOPUS:85085118610
VL - 136
JO - Bone
JF - Bone
SN - 8756-3282
M1 - 115327
ER -