The effect of continuous subcutaneous insulin infusion on insulin binding to erythrocytes in diabetes mellitus

Frank M. Ng, Erol Babacan, Matthew Cohen, Paul Z. Zimmet

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Abstract

The effect of continuous subcutaneous insulin infusion (CSII) on glycaemic control and insulin binding to erythrocytes was studied in six diabetic patients. A marked improvement in blood glucose control during CSII was observed in these patients previously on conventional therapy. Specific 125I-insulin binding to erythrocytes of the diabetics before the institution of CSII was significantly lower than that of age-, weight- and sex-matched nondiabetic subjects, 6.5 ± 0.1% vs. 9.8 ± 0.3% (P < 0.05). After 4-6 months of CSII, insulin binding was restored to normal levels. This normalization in insulin binding to erythrocytes of patients on CSII was due to a 35% increase in active binding sites, together with a small change in binding affinity.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume3
Issue number1
DOIs
Publication statusPublished - 1 Jan 1987

Keywords

  • (Diabetes mellitus)
  • Continuous subcutaneous insulin infusion
  • Erythrocyte
  • Insulin binding

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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