The CTLA4 + 49A/G and CT60 polymorphisms and chronic inflammatory arthropathies in Northern Ireland

V. Suppiah, C. O'Doherty, S. Heggarty, C. C. Patterson, M. Rooney, K. Vandenbroeck

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Rheumatoid and juvenile idiopathic arthritis (RA, JIA) are chronic inflammatory arthropathies with an autoimmune background. The cytotoxic T-lymphocyte antigen-4 (CTLA-4) protein plays a key role in the down-regulation of T cell activation. We analyzed the CTLA4 +49A/G and CT60 polymorphisms in cohorts of Northern Irish RA and JIA patients and healthy control subjects using restriction fragment length polymorphism methods. The + 49 A allele was increased in RA (61.2%; P = 0.02; OR = 1.28; 95% C.I. = 1.04-1.58) and JIA (61.8%; P = 0.14) patients compared to the control population (55.3%). No significant association was observed for the CT60 polymorphism. Haplotype analysis revealed a significantly different distribution of + 49 A/G-CT60 haplotypes in RA and JIA patients compared to controls (P value < 0.00001 and 0.030 for comparison of RA and JIA patients with controls, respectively). Our results suggest that the CTLA-4 gene is involved in predisposition to inflammatory arthropathies in the Northern Irish population.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalExperimental and Molecular Pathology
Volume80
Issue number2
DOIs
Publication statusPublished or Issued - Apr 2006
Externally publishedYes

Keywords

  • +49 A/G
  • CT60
  • CTLA-4
  • Juvenile idiopathic arthritis
  • Rheumatoid arthritis
  • Susceptibility

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

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