The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging

Dimitrios Cakouros, Stan Gronthos

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

There is mounting evidence in the literature that mesenchymal stromal/stem cell (MSC) like populations derived from different tissues, undergo epigenetic changes during aging, leading to compromised connective tissue integrity and function. This body of work has linked the biological aging of MSC to changes in their epigenetic signatures affecting growth, lifespan, self-renewal and multi-potential, due to deregulation of processes such as cellular senescence, oxidative stress, DNA damage, telomere shortening and DNA damage. This review addresses recent findings examining DNA methylation, histone modifications and miRNA changes in aging MSC populations. Moreover, we explore how epigenetic factors alter cellular pathways and associated biological networks, contributing to the MSC aging phenotype. Finally we discuss the crucial areas requiring a greater understanding of these processes, in order to piece together a global picture of the changing epigenetic landscape in MSC during aging.

Original languageEnglish
Article number115440
JournalBone
Volume137
DOIs
Publication statusPublished or Issued - Aug 2020

Keywords

  • Aging
  • DNA methylation
  • Epigenetics
  • Histome modifications
  • MSC
  • Mesenchymal Stem/Stromal Cells
  • Skeleton
  • miRNA

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

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