The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization

Donald J. Davidson, Andrew J. Currie, Gregor S.D. Reid, Dawn M.E. Bowdish, Kelly L. MacDonald, Rebecca C. Ma, Robert E.W. Hancock, David P. Speert

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Abstract

Dendritic cells (DC) are instrumental in orchestrating an appropriately polarized Th cell response to pathogens. DC exhibit considerable phenotypic and functional plasticity, influenced by lineage, Ag engagement, and the environment in which they develop and mature. In this study, we identify the human cationic peptide LL-37, found in abundance at sites of inflammation, as a potent modifier of DC differentiation, bridging innate and adaptive immune responses. LL-37-derived DC displayed significantly up-regulated endocytic capacity, modified phagocytic receptor expression and function, up-regulated costimulatory molecule expression, enhanced secretion of Th-1 inducing cytokines, and promoted Th1 responses in vitro. LL-37 may be an attractive therapeutic candidate for manipulating T cell polarization by DC.

Original languageEnglish
Pages (from-to)1146-1156
Number of pages11
JournalJournal of Immunology
Volume172
Issue number2
DOIs
Publication statusPublished or Issued - 15 Jan 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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