The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans

Luciana Ribeiro, João V. Busnello, Rita M. Cantor, Fiona Whelan, Pamela Whittaker, Panos Deloukas, Ma Li Wong, Julio Licinio

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The hypothesis that brain-derived neurotrophic factor (BDNF) is involved in the pathogenesis of major depression is supported by several research findings; however, genetic studies assessing the relationship between BDNF and psychiatric disorders have produced conflicting results. We examined the effect of a BDNF polymorphism on depression susceptibility in Mexican-Americans. The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005). Individuals homozygous for the major allele (GG) had an increased chance of being depressed (OR=1.7 95% CI 1.17-2.47). Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.

LanguageEnglish
Pages1291-1293
Number of pages3
JournalNeuroReport
Volume18
Issue number12
DOIs
Publication statusPublished - Aug 2007

Keywords

  • BDNF (brain derived neurotrophic factor)
  • Major depressive disorder
  • Mexican-Americans
  • Pharmacogenetics
  • Polymorphism
  • Psychiatry
  • rs6265
  • Single nucleotide polymorphism
  • Val66Met

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ribeiro, L., Busnello, J. V., Cantor, R. M., Whelan, F., Whittaker, P., Deloukas, P., ... Licinio, J. (2007). The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. NeuroReport, 18(12), 1291-1293. https://doi.org/10.1097/WNR.0b013e328273bcb0
Ribeiro, Luciana ; Busnello, João V. ; Cantor, Rita M. ; Whelan, Fiona ; Whittaker, Pamela ; Deloukas, Panos ; Wong, Ma Li ; Licinio, Julio. / The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. In: NeuroReport. 2007 ; Vol. 18, No. 12. pp. 1291-1293.
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Ribeiro, L, Busnello, JV, Cantor, RM, Whelan, F, Whittaker, P, Deloukas, P, Wong, ML & Licinio, J 2007, 'The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans', NeuroReport, vol. 18, no. 12, pp. 1291-1293. https://doi.org/10.1097/WNR.0b013e328273bcb0

The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. / Ribeiro, Luciana; Busnello, João V.; Cantor, Rita M.; Whelan, Fiona; Whittaker, Pamela; Deloukas, Panos; Wong, Ma Li; Licinio, Julio.

In: NeuroReport, Vol. 18, No. 12, 08.2007, p. 1291-1293.

Research output: Contribution to journalArticle

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Ribeiro L, Busnello JV, Cantor RM, Whelan F, Whittaker P, Deloukas P et al. The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. NeuroReport. 2007 Aug;18(12):1291-1293. https://doi.org/10.1097/WNR.0b013e328273bcb0