The basic fertility workup in women with polycystic ovary syndrome: A systematic review

Marleen J. Nahuis, G. Jurjen E Oosterhuis, Peter G A Hompes, Madelon Van Wely, Ben Willem J Mol, Fulco Van Der Veen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To summarize the evidence for the use of commonly accepted fertility tests in subfertile women with ovulation problems. Design: Systematic review. Setting: Not applicable. Patient(s): The study population included women starting with clomiphene citrate (CC) as first-line treatment, women starting with second-line treatment if CC failed to result in pregnancy, and women starting with second-line treatment if CC failed to result in ovulation (CC resistant). Intervention(s): Performance of a semen analysis or tubal patency test before or during treatment. Main Outcome Measure(s): Prevalence of abnormal tests as well as the diagnostic and prognostic performance of these tests. Result(s): Four studies reported on 3,017 women starting with CC as first-line treatment. The prevalence of male factor infertility was 10%, and in 0.3% of couples azoospermia was found (two studies). Semen parameters were not associated with pregnancy chance (one study). The prevalence of bilateral tubal disease was 4% (two studies). Three studies reported on 462 women starting with second-line treatment if CC failed to result in a pregnancy. Semen parameters were not predictive for pregnancy (one study). The prevalence of bilateral tubal disease in these women was 8% (three studies). Two studies reported on 168 CC-resistant women and total motile sperm count did not predict live birth (two studies). For all other outcomes, no studies were available. Conclusion(s): Data on the basic fertility workup in subfertile women with anovulation are scarce. Based on the available data, the workup should contain a semen analysis, and, for women who need to start second-line treatment if CC failed to result in pregnancy or women with CC resistance, assessment of tubal patency.

LanguageEnglish
Pages219-225
Number of pages7
JournalFertility and Sterility
Volume100
Issue number1
DOIs
Publication statusPublished - 1 Jul 2013

Keywords

  • Anovulation
  • Chlamydia antibody titer
  • clomiphene citrate
  • semen analysis
  • tubal pathology

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Nahuis, M. J., Oosterhuis, G. J. E., Hompes, P. G. A., Van Wely, M., Mol, B. W. J., & Van Der Veen, F. (2013). The basic fertility workup in women with polycystic ovary syndrome: A systematic review. Fertility and Sterility, 100(1), 219-225. https://doi.org/10.1016/j.fertnstert.2013.03.015
Nahuis, Marleen J. ; Oosterhuis, G. Jurjen E ; Hompes, Peter G A ; Van Wely, Madelon ; Mol, Ben Willem J ; Van Der Veen, Fulco. / The basic fertility workup in women with polycystic ovary syndrome : A systematic review. In: Fertility and Sterility. 2013 ; Vol. 100, No. 1. pp. 219-225.
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abstract = "Objective: To summarize the evidence for the use of commonly accepted fertility tests in subfertile women with ovulation problems. Design: Systematic review. Setting: Not applicable. Patient(s): The study population included women starting with clomiphene citrate (CC) as first-line treatment, women starting with second-line treatment if CC failed to result in pregnancy, and women starting with second-line treatment if CC failed to result in ovulation (CC resistant). Intervention(s): Performance of a semen analysis or tubal patency test before or during treatment. Main Outcome Measure(s): Prevalence of abnormal tests as well as the diagnostic and prognostic performance of these tests. Result(s): Four studies reported on 3,017 women starting with CC as first-line treatment. The prevalence of male factor infertility was 10{\%}, and in 0.3{\%} of couples azoospermia was found (two studies). Semen parameters were not associated with pregnancy chance (one study). The prevalence of bilateral tubal disease was 4{\%} (two studies). Three studies reported on 462 women starting with second-line treatment if CC failed to result in a pregnancy. Semen parameters were not predictive for pregnancy (one study). The prevalence of bilateral tubal disease in these women was 8{\%} (three studies). Two studies reported on 168 CC-resistant women and total motile sperm count did not predict live birth (two studies). For all other outcomes, no studies were available. Conclusion(s): Data on the basic fertility workup in subfertile women with anovulation are scarce. Based on the available data, the workup should contain a semen analysis, and, for women who need to start second-line treatment if CC failed to result in pregnancy or women with CC resistance, assessment of tubal patency.",
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Nahuis, MJ, Oosterhuis, GJE, Hompes, PGA, Van Wely, M, Mol, BWJ & Van Der Veen, F 2013, 'The basic fertility workup in women with polycystic ovary syndrome: A systematic review', Fertility and Sterility, vol. 100, no. 1, pp. 219-225. https://doi.org/10.1016/j.fertnstert.2013.03.015

The basic fertility workup in women with polycystic ovary syndrome : A systematic review. / Nahuis, Marleen J.; Oosterhuis, G. Jurjen E; Hompes, Peter G A; Van Wely, Madelon; Mol, Ben Willem J; Van Der Veen, Fulco.

In: Fertility and Sterility, Vol. 100, No. 1, 01.07.2013, p. 219-225.

Research output: Contribution to journalArticle

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Nahuis MJ, Oosterhuis GJE, Hompes PGA, Van Wely M, Mol BWJ, Van Der Veen F. The basic fertility workup in women with polycystic ovary syndrome: A systematic review. Fertility and Sterility. 2013 Jul 1;100(1):219-225. https://doi.org/10.1016/j.fertnstert.2013.03.015