The bacterial outer membrane as a drug barrier

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The outer membranes of Gram-negative bacteria constitute a semi-permeable barrier, as indicated by the corresponding alterations in outer membrane permeability and in antibiotic susceptibility resulting from mutation or polycation action. Restricted outer membrane permeability works in synergy with co-determinant resistance mechanisms, such as the periplasmic enzyme β-lactamase or active efflux mechanisms, bringing about antibiotic resistance.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalTrends in Microbiology
Issue number1
Publication statusPublished - 1 Jan 1997
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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