The association between total phthalate concentration and non-communicable diseases and chronic inflammation in South Australian urban dwelling men

Peter Y. Bai, Gary Wittert, Anne W. Taylor, Sean A. Martin, Robert W. Milne, Alicia J. Jenkins, Andrzej S. Januszewski, Zumin Shi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective To investigate associations between urinary total phthalate concentration, chronic low-grade inflammation and non-communicable diseases in a cohort of South Australian men. Methods 1504 men aged 39–84 years who provided a urinary sample at the follow-up visit of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study, a randomly-selected group of urban-dwelling, community-based men from Adelaide, Australia (n = 2038; study participation rate: 78.1%). Total phthalate concentration was quantified in fasting morning urine samples. Chronic diseases were assessed through self-report questionnaire or directly measured using standardised clinical and laboratory procedures. Inflammatory biomarkers were assayed by ELISA or spectroscopy. Multivariable linear and logistic regression models were applied to determine associations of log-transformed urinary phthalate concentration with inflammation and chronic disease. Results Total phthalates were detected in 99.6% of urinary samples; geometric mean (95% CI) was 114.1 (109.5–118.9) µg/g creatinine. Higher total phthalate levels were associated with higher levels of hs-CRP, IL-6 (all p < 0.05) and TNF-α but not MPO. Urinary total phthalate concentrations were positively associated with cardiovascular disease, type-2-diabetes and hypertension. Comparing extreme quartiles of total phthalate, prevalence ratios were 1.78 (95% CI 1.17 – 2.71, p-trend = 0.001) for cardiovascular disease and 1.84 (95%CI 1.34 – 2.51, p-trend = 0.001) for type-2-diabetes and 1.14 (95%CI 1.01 – 1.29, p-trend = 0.013) for hypertension. Total phthalates and asthma and depression were not significantly associated. Conclusion A positive association between total phthalates and cardiovascular disease, type-2-diabetes, hypertension and increased levels of chronic low-grade inflammatory biomarkers was observed in urban-dwelling Australian men.

LanguageEnglish
Pages366-372
Number of pages7
JournalEnvironmental Research
Volume158
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Australian male adults
  • Cardiovascular disease
  • Inflammation
  • Type-2-diabetes
  • Urinary total phthalates

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

@article{b16349ce62074c0e8087c92f53eeaec4,
title = "The association between total phthalate concentration and non-communicable diseases and chronic inflammation in South Australian urban dwelling men",
abstract = "Objective To investigate associations between urinary total phthalate concentration, chronic low-grade inflammation and non-communicable diseases in a cohort of South Australian men. Methods 1504 men aged 39–84 years who provided a urinary sample at the follow-up visit of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study, a randomly-selected group of urban-dwelling, community-based men from Adelaide, Australia (n = 2038; study participation rate: 78.1{\%}). Total phthalate concentration was quantified in fasting morning urine samples. Chronic diseases were assessed through self-report questionnaire or directly measured using standardised clinical and laboratory procedures. Inflammatory biomarkers were assayed by ELISA or spectroscopy. Multivariable linear and logistic regression models were applied to determine associations of log-transformed urinary phthalate concentration with inflammation and chronic disease. Results Total phthalates were detected in 99.6{\%} of urinary samples; geometric mean (95{\%} CI) was 114.1 (109.5–118.9) µg/g creatinine. Higher total phthalate levels were associated with higher levels of hs-CRP, IL-6 (all p < 0.05) and TNF-α but not MPO. Urinary total phthalate concentrations were positively associated with cardiovascular disease, type-2-diabetes and hypertension. Comparing extreme quartiles of total phthalate, prevalence ratios were 1.78 (95{\%} CI 1.17 – 2.71, p-trend = 0.001) for cardiovascular disease and 1.84 (95{\%}CI 1.34 – 2.51, p-trend = 0.001) for type-2-diabetes and 1.14 (95{\%}CI 1.01 – 1.29, p-trend = 0.013) for hypertension. Total phthalates and asthma and depression were not significantly associated. Conclusion A positive association between total phthalates and cardiovascular disease, type-2-diabetes, hypertension and increased levels of chronic low-grade inflammatory biomarkers was observed in urban-dwelling Australian men.",
keywords = "Australian male adults, Cardiovascular disease, Inflammation, Type-2-diabetes, Urinary total phthalates",
author = "Bai, {Peter Y.} and Gary Wittert and Taylor, {Anne W.} and Martin, {Sean A.} and Milne, {Robert W.} and Jenkins, {Alicia J.} and Januszewski, {Andrzej S.} and Zumin Shi",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.envres.2017.06.021",
language = "English",
volume = "158",
pages = "366--372",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press Inc.",

}

The association between total phthalate concentration and non-communicable diseases and chronic inflammation in South Australian urban dwelling men. / Bai, Peter Y.; Wittert, Gary; Taylor, Anne W.; Martin, Sean A.; Milne, Robert W.; Jenkins, Alicia J.; Januszewski, Andrzej S.; Shi, Zumin.

In: Environmental Research, Vol. 158, 01.01.2017, p. 366-372.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The association between total phthalate concentration and non-communicable diseases and chronic inflammation in South Australian urban dwelling men

AU - Bai, Peter Y.

AU - Wittert, Gary

AU - Taylor, Anne W.

AU - Martin, Sean A.

AU - Milne, Robert W.

AU - Jenkins, Alicia J.

AU - Januszewski, Andrzej S.

AU - Shi, Zumin

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective To investigate associations between urinary total phthalate concentration, chronic low-grade inflammation and non-communicable diseases in a cohort of South Australian men. Methods 1504 men aged 39–84 years who provided a urinary sample at the follow-up visit of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study, a randomly-selected group of urban-dwelling, community-based men from Adelaide, Australia (n = 2038; study participation rate: 78.1%). Total phthalate concentration was quantified in fasting morning urine samples. Chronic diseases were assessed through self-report questionnaire or directly measured using standardised clinical and laboratory procedures. Inflammatory biomarkers were assayed by ELISA or spectroscopy. Multivariable linear and logistic regression models were applied to determine associations of log-transformed urinary phthalate concentration with inflammation and chronic disease. Results Total phthalates were detected in 99.6% of urinary samples; geometric mean (95% CI) was 114.1 (109.5–118.9) µg/g creatinine. Higher total phthalate levels were associated with higher levels of hs-CRP, IL-6 (all p < 0.05) and TNF-α but not MPO. Urinary total phthalate concentrations were positively associated with cardiovascular disease, type-2-diabetes and hypertension. Comparing extreme quartiles of total phthalate, prevalence ratios were 1.78 (95% CI 1.17 – 2.71, p-trend = 0.001) for cardiovascular disease and 1.84 (95%CI 1.34 – 2.51, p-trend = 0.001) for type-2-diabetes and 1.14 (95%CI 1.01 – 1.29, p-trend = 0.013) for hypertension. Total phthalates and asthma and depression were not significantly associated. Conclusion A positive association between total phthalates and cardiovascular disease, type-2-diabetes, hypertension and increased levels of chronic low-grade inflammatory biomarkers was observed in urban-dwelling Australian men.

AB - Objective To investigate associations between urinary total phthalate concentration, chronic low-grade inflammation and non-communicable diseases in a cohort of South Australian men. Methods 1504 men aged 39–84 years who provided a urinary sample at the follow-up visit of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study, a randomly-selected group of urban-dwelling, community-based men from Adelaide, Australia (n = 2038; study participation rate: 78.1%). Total phthalate concentration was quantified in fasting morning urine samples. Chronic diseases were assessed through self-report questionnaire or directly measured using standardised clinical and laboratory procedures. Inflammatory biomarkers were assayed by ELISA or spectroscopy. Multivariable linear and logistic regression models were applied to determine associations of log-transformed urinary phthalate concentration with inflammation and chronic disease. Results Total phthalates were detected in 99.6% of urinary samples; geometric mean (95% CI) was 114.1 (109.5–118.9) µg/g creatinine. Higher total phthalate levels were associated with higher levels of hs-CRP, IL-6 (all p < 0.05) and TNF-α but not MPO. Urinary total phthalate concentrations were positively associated with cardiovascular disease, type-2-diabetes and hypertension. Comparing extreme quartiles of total phthalate, prevalence ratios were 1.78 (95% CI 1.17 – 2.71, p-trend = 0.001) for cardiovascular disease and 1.84 (95%CI 1.34 – 2.51, p-trend = 0.001) for type-2-diabetes and 1.14 (95%CI 1.01 – 1.29, p-trend = 0.013) for hypertension. Total phthalates and asthma and depression were not significantly associated. Conclusion A positive association between total phthalates and cardiovascular disease, type-2-diabetes, hypertension and increased levels of chronic low-grade inflammatory biomarkers was observed in urban-dwelling Australian men.

KW - Australian male adults

KW - Cardiovascular disease

KW - Inflammation

KW - Type-2-diabetes

KW - Urinary total phthalates

UR - http://www.scopus.com/inward/record.url?scp=85021773073&partnerID=8YFLogxK

U2 - 10.1016/j.envres.2017.06.021

DO - 10.1016/j.envres.2017.06.021

M3 - Article

VL - 158

SP - 366

EP - 372

JO - Environmental Research

T2 - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -